CIS-5-BENZYL-2-BOC-HEXAHYDROPYRROLO[3,4-C]PYRROLE

To a solution of (3aR, 6a5)-2-benzyloctahydropyrrolo[3, 4-c]pyrrole (10 g, 49.5 mmol) in THF (100 mL) was added DIPEA (12.8 g, 99 mmol) and Boc2O (10.8 g, 49.5 mmol). The reaction mixture was stirred at ambient temperature for 5 h before diluting with ethyl acetate. The reaction mixture was washed with aq. NaHCO3 and brine. The organic layer was dried over anhydroussodium sulfate, filtered and evaporated to provide (3aR, 6a5)-tert-butyl 5- benzylhexahydropyrrolo[3, 4-c]pyrrole-2(1H)-carboxylate as a yellow oil (12 g, 80 percent).To a solution of (3aR, 6aS)-2-benzyloctahydropyrrolo[3, 4-c]pyrrole (10 g, 49.5 mmol) in tetrahydrofuran (100 mL) was added DIPEA (12.8 g, 99 mmol) and Boc

Molecular Weight:302.4
XLogP3:2.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:302.199428076
Monoisotopic Mass:302.199428076
Topological Polar Surface Area:32.8
Heavy Atom Count:22
Complexity:384
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes