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Home > Encyclopedia > Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)-

Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)-

Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)- structure

Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)- 

structure
  • CAS No:

    14158-66-8

  • Formula:

    C26H28ClNO.ClH

  • Chemical Name:

    Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)-

  • Synonyms:

    Triethylamine,2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-,hydrochloride,(Z)-

Description

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.

Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)- Basic Attributes

442.42056

441.163

DTXSID20747369

Characteristics

12.5

149-150.5 °C

Drug Information

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)|Compounds which increase the capacity to conceive in females. (See all compounds classified as Fertility Agents, Female.)|A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63) (See all compounds classified as Selective Estrogen Receptor Modulators.)

Chloramiphene

Triethylamine, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]-, hydrochloride, (Z)- Use and Manufacturing

Cis isomer of Clomiphene (C587025). Found to be antiestrogenic and a more potent inhibitor of LH secretion than the trans isomer.

Computed Properties

Molecular Weight:442.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:9
Exact Mass:441.1626199
Monoisotopic Mass:441.1626199
Topological Polar Surface Area:12.5
Heavy Atom Count:30
Complexity:481
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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