Afobazole
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Afobazole
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CAS No:
173352-21-1
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Formula:
C15H21N3O2S
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Chemical Name:
Afobazole
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Synonyms:
1H-Benzimidazole,6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-;1H-Benzimidazole,5-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-;6-Ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole;CM 346;Afobazole;Afobazol;Aphobazole;Fabomotizole
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CAS No:
Description
Fabomotizole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.IC50 value:Target: anxiolytic agent Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with seroton
Fabomotizole is a member of benzimidazoles.
Computed Properties
Molecular Weight:307.4
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:307.13544809
Monoisotopic Mass:307.13544809
Topological Polar Surface Area:75.7
Heavy Atom Count:21
Complexity:315
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes