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Clorgyline

Clorgyline structure

CAS No:
17780-72-2
Formula:
C13H15Cl2NO
Chemical Name:
Clorgyline
Synonyms:
2-Propyn-1-amine,N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-;2-Propynylamine,N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-;N-[3-(2,4-Dichlorophenoxy)propyl]-N-methyl-2-propyn-1-amine;M & B 9302;M and B 9302;Clorgyline;Clorgiline;[3-(2,4-Dichlorophenoxy)propyl](methyl)(2-propynyl)amine
Categories:
Organic Chemistry > Amides

Description

ChEBI: An aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant.

Clorgyline is an aromatic ether that is the 2,4-dichlorophenyl ether of 3-aminopropan-1-ol in which the nitrogen is substituted by a methyl group and a prop-1-yn-3-yl group. A monoamine oxidase inhibitor, it was formerly used as an antidepressant. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and an antidepressant. It is a tertiary amino compound, a terminal acetylenic compound, an aromatic ether and a dichlorobenzene.|An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.

Clorgyline Basic Attributes

Molecular Weight：

272.1703

Exact Mass：

272.17

UNII：

LYJ16FZU9Q

DSSTox ID：

DTXSID3048445

HScode：

2922299090

Characteristics

PSA：

12.5

XLogP3：

3.32730

Density：

1.196g/cm3

Boiling Point：

361.3ºC at 760mmHg

Flash Point：

172.3ºC

Refractive Index：

1.546

Drug Information

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)

MeSH Entry Terms：

Chlorgyline

Computed Properties

Molecular Weight:272.17
XLogP3:4.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:271.0530695
Monoisotopic Mass:271.0530695
Topological Polar Surface Area:12.5
Heavy Atom Count:17
Complexity:263
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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