(6-Chloro-3-pyridinyl)-4-morpholinylmethanone
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(6-Chloro-3-pyridinyl)-4-morpholinylmethanone
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CAS No:
64614-49-9
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Formula:
C10H11ClN2O2
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Chemical Name:
(6-Chloro-3-pyridinyl)-4-morpholinylmethanone
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Synonyms:
Methanone,(6-chloro-3-pyridinyl)-4-morpholinyl-;Morpholine,4-[(6-chloro-3-pyridinyl)carbonyl]-;(6-Chloro-3-pyridinyl)-4-morpholinylmethanone;4-[(6-Chloro-3-pyridinyl)carbonyl]morpholine;1-(6-Chloropyridin-3-yl)-1-morpholin-4-ylmethanone;(6-Chloropyridin-3-yl)morpholin-4-ylmethanone
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CAS No:
(6-Chloro-3-pyridinyl)-4-morpholinylmethanone Basic Attributes
226.66
226.66
DTXSID70357654
2934999090
Safety Information
IRRITANT
NONH for all modes of transport
22-36
26
Xn
P305 + P351 + P338
H302-H319
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
(6-Chloro-3-pyridinyl)-4-morpholinylmethanone Use and Manufacturing
To 6-chloro-nicotinoyl chloride (0.540g, 3.07mmoles) in dichloromethane (10mL) was added of morpholine, (0.294g , 1.1 equivalents) followed by triethylamine (940uL, 2.2 equivalents). The reaction was stirred overnight at room temperature to give (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone. No starting material, 6-Chloro-nicotinoyl chloride, remained and mass spectrometry showed correct M+ ion. An aqueous work-up was performed and the crude material was taken to the next step. The crude residue, (6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone, weighed 0.610g (88percent yield) after aqueous work-up.
(6-Chloro-3-pyridinyl)-4-morpholinylmethanone
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