5-Chloro-1H-indole-2-carboxylic acid
-
5-Chloro-1H-indole-2-carboxylic acid
structure -
-
CAS No:
10517-21-2
-
Formula:
C9H6ClNO2
-
Chemical Name:
5-Chloro-1H-indole-2-carboxylic acid
-
Synonyms:
1H-Indole-2-carboxylic acid,5-chloro-;Indole-2-carboxylic acid,5-chloro-;5-Chloro-1H-indole-2-carboxylic acid;5-Chloroindole-2-carboxylic acid;NSC 75651;2-Carboxy-5-chloroindole
- Categories:
-
CAS No:
Description
light pink to beige or light brown fine
5-chloro-1H-indole-2-carboxylic acid is an indolyl carboxylic acid.
5-Chloro-1H-indole-2-carboxylic acid Basic Attributes
195.6
195.60
153229
234-050-1
75651
DTXSID60146993
29339990
Characteristics
53.1
2.9
1.3228 (rough estimate)
152 °C @ Solvent: Diisopropyl ether
449.7±25.0 °C(Predicted)
225.8±23.2 °C
1.5790 (estimate)
0-6°C
Safety Information
IRRITANT
NONH for all modes of transport
3
22-36/37/38
26-36-37/39
NL5998400
Xn,Xi
P261-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Chloro-1H-indole-2-carboxylic acid Use and Manufacturing
A mixture of 111.5 g of 5-chloroindole-2-carboxylate in 31.25 g of 96percent sodium hydroxide, 183 ml of methanol and 183 ml of water was heated under reflux for 1 hour, cooled to 40 ° C, Dropping 10percent hydrochloric acid to pH 3 to 4, fully cooled, The product was filtered to give 90.1 g of an off-white indole-2-carboxylic acid in a yield of 92.5percent and an HPLC content of ≥96percentA mixture of compound 3a (33.5 g, 0.15 mol), 4percent NaOH solution (335 mL) and ethanol (335 mL) was heated to reflux for 3 h. Upon cooling to room temperature, the mixture was poured into ice-water, adjusted to pH 5 with glacial acetic acid, and then the precipitate was collected by filtration. 4a was obtained as a white solid (26.4 g, 90percent). m.p. 295-298 °C. ESI-MS m/z: 193.4 (Cl = 35), 195.4 (Cl = 37) [M - H]
NMDA receptor antagonist (gly)
Computed Properties
Molecular Weight:195.60
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:195.0087061
Monoisotopic Mass:195.0087061
Topological Polar Surface Area:53.1
Heavy Atom Count:13
Complexity:222
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 5-Chloro-1H-indole-2-carboxylic acid
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
8 YRS
Business licensed Certified factoryManufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances ChemicalsInquiryCAS No.: 10517-21-2Grade: Pharmaceutical GradeContent: 99%
Learn More Other Chemicals
-
3,5-DIBROMO-2-[[[(3,5-DINITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
535965-38-9
-
3,5-DIBROMO-2-[[[[(2-CHLOROPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532386-89-3
-
3,5-DIBROMO-2-[[[(4-METHYL-3-NITROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID
532943-48-9
-
3,5-DIBROMO-2-[[[[3-(2-FURANYL)-1-OXO-2-PROPENYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
586392-09-8
-
3,5-DIBROMO-2-[[[[(2-METHYLPHENOXY)ACETYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Formula
531548-30-8
-
2-(1,8-dibromo-16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid Formula
333340-54-8
-
3,5-DIBROMO-2-[[[[3-(PHENOXYMETHYL)BENZOYL]AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
586393-79-5
-
3,5-DIBROMO-2-[[[(4-CHLOROBENZOYL)AMINO]THIOXOMETHYL]AMINO]-BENZOIC ACID Structure
531530-32-2
-
What is 2-Cyclopentyl-3-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-oxo-4-isoquinolinecarboxylic acid
400073-92-9
-
What is 9-Octadecenoic acid (9Z)-, compd. with N,N-dimethylcyclohexanamine (1:1)
65122-23-8
5-Chloro-1H-indole-2-carboxylic acid
SDSRequest for Quotation