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Migalastat hydrochloride

Migalastat hydrochloride structure

CAS No:
75172-81-5
Formula:
C6H13NO4.ClH
Chemical Name:
Migalastat hydrochloride
Synonyms:
3,4,5-Piperidinetriol,2-(hydroxymethyl)-,hydrochloride (1:1),(2R,3S,4R,5S)-;3,4,5-Piperidinetriol,2-(hydroxymethyl)-,hydrochloride,[2R-(2α,3α,4α,5β)]-;3,4,5-Piperidinetriol,2-(hydroxymethyl)-,hydrochloride,(2R,3S,4R,5S)-;Migalastat hydrochloride;1-Deoxygalactonojirimycin hydrochloride;Galafold
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Migalastat hydrochloride (1-Deoxygalactonojirimycin hydrochloride) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC50 of 0.04 μM for human α-Gal A.

Migalastat hydrochloride Basic Attributes

Molecular Weight：

199.63

Exact Mass：

199.06100

UNII：

CLY7M0XD20

ATC Code：

A16AX

HScode：

29333990

Characteristics

PSA：

XLogP3：

-1.83600

Melting Point：

243-245 °C (decomp)

Boiling Point：

382.7ºC at 760 mmHg

Flash Point：

185.2ºC

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (97.56%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Galafold is indicated for long-term treatment of adults and adolescents aged 16 years and older with a confirmed diagnosis of Fabry disease (α-galactosidase A deficiency) and who have an amenable mutation.|Treatment of Fabry disease

MeSH Entry Terms：

1-butyl-2-(hydroxylmethyl)piperidine-3,4,5-triol

Migalastat hydrochloride Use and Manufacturing

Uses

inhibitor of b-glucosidase

Use Classification：

Human drugs -> Orphan -> Galafold -> EMA Drug Category|migalastat -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:199.63
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:199.0611356
Monoisotopic Mass:199.0611356
Topological Polar Surface Area:93
Heavy Atom Count:12
Complexity:132
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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1-Deoxygalactonojirimycin Hydrochloride

CAS No.: 75172-81-5

Content: 99.00%

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