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DESMETHYL SILDENAFIL

DESMETHYL SILDENAFIL structure

CAS No:
139755-82-1
Formula:
C21H28N6O4S
Chemical Name:
DESMETHYL SILDENAFIL
Synonyms:
DESMETHYL SILDENAFIL;5-[2-Ethoxy-5-(1-piperazinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl- 7H-pyrazolo[4,3-d]pyrimidin-7-one;UK 103320;Sildenafil N-DesMethylIMpurity;Sildenafil N-DesMethyl Metabolite;Sildenafil N-desmethy impurity;5-(2-Ethoxy-5-(piperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one;Sildenafil N-desmethyl
Categories:
Pharmaceutical Intermediates > Analgesics

Description

White Solid

A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.

DESMETHYL SILDENAFIL Basic Attributes

Molecular Weight：

460.55

Exact Mass：

460.18900

UNII：

L6WO34R9YG

DSSTox ID：

DTXSID00161160

Characteristics

PSA：

126

XLogP3：

Density：

1.44±0.1 g/cm3(Predicted)

Melting Point：

158-160°C

Boiling Point：

685.7°C at 760 mmHg

Flash Point：

368.5ºC

Refractive Index：

1.683

Storage Conditions：

-20°C Freezer

Vapor Pressure：

1.17E-18mmHg at 25°C

Safety Information

Stability/Shelf Life：

Moisture Sensitive

Precautionary statement(s)：

P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P501

Hazard Statements：

H302

Drug Information

MeSH：

Compounds that specifically inhibit PHOSPHODIESTERASE 5. (See all compounds classified as Phosphodiesterase 5 Inhibitors.)|Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate

DESMETHYL SILDENAFIL Use and Manufacturing

A metabolite of Sildenafil, an orally active selective type 5 cGMP phosphodiesterase inhibitor

Computed Properties

Molecular Weight:460.6
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:460.18927457
Monoisotopic Mass:460.18927457
Topological Polar Surface Area:126
Heavy Atom Count:32
Complexity:810
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes