4,7-DIAZA-SPIRO[2.5]OCTANE DIHYDROCHLORIDE

In a sealed tube, 7-fluoro-2-(2-methyl-[l, 2, 4]triazolo[l, 5-b]pyridazin-6-yl)-4H-pyrido[l, 2- a]pyrimidin-4-one (Intermediate (VI-2), 20 mg, 0.068 mmol), TEA (102 mg, 141 mu, 1.01 mmol, 15 eq.) and In a sealed tube, 7-fluoro-2-(2-methyl-[l, 2, 4]triazolo[l, 5-a]pyrimidin-6-yl)-4H-pyrido[l, 2- a]pyrimidin-4-one (Intermediate (VI- 1); 50 mg, 0.169 mmol), Example 28 7 4, 7-diazaspiro[2.5]octan-7-yl)-2^2, 8-dimethylimidazo[l, 2-b]pyridazin-6-yl)-9-methyl- pyrido[l, 2-a]pyrimidin-4-one In a sealed tube, 2-(2, 8-dimethylimidazo[l, 2-b]pyridazin-6-yl)-7-fluoro-9-methyl- pyrido[l, 2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol), DIPEA (0.21 mL, 1.24 mmol, 8 eq.) and In a sealed tube, 2-(2, 8-dimethylimidazo[l, 2-b]pyridazin-6-yl)-7-fluoro-9-methyl- pyrido[l, 2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol), DIPEA (0.21 mL, 1.24 mmol, 8 eq.) and In a sealed tube, 2- (2, 8-dimethylimidazo [1 , 2-b]pyridazin-6-yl)-7-fluoro-9-methyl- pyrido[1, 2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol), DIPEA (0.21 mL, 1.24mmol, 8 eq.) and In a sealed tube, 2-(2, 8-dimethylimidazo[1, 2-b]pyridazin-6-yl)-7-fluoro-9-methyl-pyrido[1, 2-a]pyrimidin-4-one (Intermediate 4; 50 mg, 0.155 mmol), DIPEA (0.21 mL, 1.24 mmol, 8 eq.) and Example 37 7-(4, 7-diazaspiro[2.5]octan-7-yl)-9-methyl-2-(2-methylimidazo[l, 2-b]pyridazin-6- yl)pyrido[l, 2-a]pyrimidin-4-one In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo[l, 2-b]pyridazin-6-yl)pyrido[l, 2- a]pyrimidin-4-one (Intermediate 3; 125 mg, 0.404 mmol), K2C03 (223 mg, 1.62 mmol, 4 eq.) and In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo[l, 2-b]pyridazin-6-yl)pyrido[l, 2- a]pyrimidin-4-one (Intermediate 3; 125 mg, 0.404 mmol), K2C03(223 mg, 1.62 mmol, 4 eq.) and In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo [1 , 2-b]pyridazin-6-yl)pyrido [1, 2- a]pyrimidin-4-one (Intermediate 3; 125 mg, 0.404 mmol), K2C03 (223 mg, 1.62 mmol, 4 eq.)and In a sealed tube, 7-fluoro-9-methyl-2-(2-methylimidazo[1, 2-b]pyridazin-6-yl)pyrido[1, 2-a]pyrimidin-4-one (Intermediate 3; 125 mg, 0.404 mmol), K2CO3 (223 mg, 1.62 mmol, 4 eq.) and Example 20 7-(4, 7-diazaspiro[2.5]octan-7-yl)-2-(2, 8-dimethylimidazo[l, 2-b]pyridazin-6- yl)pyrido[l, 2-a]pyrimidin-4-one In a sealed tube, 2-(2, 8-dimethylimidazo[l, 2-b]pyridazin-6-yl)-7-fluoro-pyrido[l, 2- a]pyrimidin-4-one (Intermediate 2; 50 mg, 0.162 mmol), DIPEA (0.22 mL, 1.29 mmol, 4 eq.) and In a sealed tube, 2-(2, 8-dimethylimidazo[l, 2-b]pyridazin-6-yl)-7-fluoro-pyrido[l, 2- a]pyrimidin-4-one (Intermediate 2; 50 mg, 0.162 mmol), DIPEA (0.22 mL, 1.29 mmol, 4 eq.) and Tn a sealed tube, 2- (2, 8-dimethylimidazo [1 , 2-b]pyridazin-6-yl)-7-fluoro-pyrido [1, 2- a]pyrimidin-4-one (Intermediate 2; 50 mg, 0.162 mmol), DIPEA (0.22 mL, 1.29 mmol, 4 eq.)and In a sealed tube, 2-(2, 8-dimethylimidazo[1, 2-b]pyridazin-6-yl)-7-fluoro-pyrido[1, 2-a]pyrimidin-4-one (Intermediate 2; 50 mg, 0.162 mmol), DIPEA (0.22 mL, 1.29 mmol, 4 eq.) and Example 19 7-(4, 7-diazaspiro[2.5]octan-7-yl)-2-(2-methylimidazo[l, 2-b]pyridazin-6-yl)pyrido[l, 2- a]pyrimidin-4-one In a sealed tube, 7-fluoro-2-(2-methylimidazo[l, 2-b]pyridazin-6-yl)-4H-pyrido[l, 2- a]pyrimidin-4-one (Intermediate 1; 50 mg, 0.169 mmol), DIPEA (0.24 mL, 1.35 mmol, 8 eq.) and In a sealed tube, 7-fluoro-2-(2-methylimidazo[l, 2-b]pyridazin-6-yl)-4H-pyrido[l, 2- a]pyrimidin-4-one (Intermediate 1; 50 mg, 0.169 mmol), DIPEA (0.24 mL, 1.35 mmol, 8 eq.) and Tn a sealed tube, 7-fluoro-2-(2-methylimidazo [1 , 2-b]pyridazin-6-yl)-4H-pyrido [1, 2- a]pyrimidin-4-one (Intermediate 1; 50 mg, 0.169 mmol), DIPEA (0.24 mL, 1.35 mmol, 8 eq.) and In a sealed tube, 7-fluoro-2-(2-methylimidazo[1, 2-b]pyridazin-6-yl)-4H-pyrido[1, 2-a]pyrimidin-4-one (Intermediate 1; 50 mg, 0.169 mmol), DIPEA (0.24 mL, 1.35 mmol, 8 eq.) and Example 39 4, 7-diazaspiro[2.5]oct-7-yl(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)methanone The product from Example 1D (181 mg, 0.540 mmol) was subjected to the conditions described in Example 2, substituting

Molecular Weight:185.09
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:2
Exact Mass:184.0534038
Monoisotopic Mass:184.0534038
Topological Polar Surface Area:24.1
Heavy Atom Count:10
Complexity:96.7
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes