2,8-DIAZASPIRO[4.5]DECAN-3-ONE
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![2,8-DIAZASPIRO[4.5]DECAN-3-ONE structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/102677c0ff54464bb04f1d114802f683.png "2,8-DIAZASPIRO[4.5]DECAN-3-ONE")
2,8-DIAZASPIRO[4.5]DECAN-3-ONE
structure -
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CAS No:
561314-57-6
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Formula:
C8H14N2O
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Chemical Name:
2,8-DIAZASPIRO[4.5]DECAN-3-ONE
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Synonyms:
2,8-DIAZASPIRO[4.5]DECAN-3-ONE;2,8-Diazaspiro[4.5]decan-...;2,8-diazaspiro[4.5]decan-3-one(SALTDATA: 2HCl);3,8-Diazaspiro[4.5]decan-2-one HCl
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CAS No:
Safety Information
20/21/22-36/37/38
26-36
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2,8-DIAZASPIRO[4.5]DECAN-3-ONE Use and Manufacturing
(920 mg, 3.62 mmol) in DCM /TFA (5mL / 5mL) mixture. Stirred for 12 hours at 30 deg.C. TLC (PE: ethyl acetate = 1: 1) showed complete. The reaction mixture was concentrated under reduced pressure to give the crude product, the crude product was dissolved in water (30 mL) with sodium hydroxide solution(1N) was adjusted to pH 10; the mixture was extracted with dichloromethane(15mL × 4). The combined organic layers were dried over anhydrous sodium sulfate and concentrated to give the title compound (550mg, yield 98percent) as a yellow oil.
Computed Properties
Molecular Weight:154.21
XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:154.110613074
Monoisotopic Mass:154.110613074
Topological Polar Surface Area:41.1
Heavy Atom Count:11
Complexity:173
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
