4,6-Dichloro-2-pyridinecarboxylic acid
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4,6-Dichloro-2-pyridinecarboxylic acid
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CAS No:
88912-25-8
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Formula:
C6H3Cl2NO2
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Chemical Name:
4,6-Dichloro-2-pyridinecarboxylic acid
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Synonyms:
4,6-Dichloro-2-pyridinecarboxylic acid;4,6-DICHLOROPICOLINIC ACID;4,6-dichloropyridine-2-carboxylic acid;2-Carboxy-4,6-dichloropyridine, 4,6-Dichloropicolinic acid;2-Pyridinecarboxylic acid, 4,6-dichloro-;4,6-dichloropicolinic acid 4,6-dichloropicolinic acid
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CAS No:
Safety Information
|Warning|H302 (66.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4,6-Dichloro-2-pyridinecarboxylic acid Use and Manufacturing
(3) Lithium hydroxide monohydrate (1.46 g, 34.9 mmol) was added to a solution of methyl 4, 6-dichloropicolinate (4.8 g, 23.3 mmol) in methanol: water (100 mL, 1 :0.1 v/v) at 0°C. The reaction mixture was warmed to room temperature and stirred for 16h. The reaction mixture was concentrated under reduced pressure to get crude product which was diluted with water. The crude was acidified by 2N hydrochloric acid at 0°C to get white precipitate. The precipitate was filtered and dried under vacuum to get 3.0 g of 4, 6-dichloropicolinic acid. Yield: 67percent. (0661) ES-MS [M+H]Butyllithium (2.5 M/L in THF) (3.9 mL, 9.77 mmol) was diluted in tetrahydrofuran (10 mL) and cooled to -78 C under argon. Acetonitrile (0.548 mL, 10.4 mmol) was added dropwise and the solution was stirred at -78C for 30 min. A solution of Butyllithium (2.5 M/L in THF) (3.9 mL, 9.77 mmol) was diluted in tetrahydrofuran (10 mL) and cooled to -78 C under argon. Acetonitrile (0.548 mL, 10.4 mmol) was added dropwise and the solution was stirred at -78C for 30 min. A solution of
Computed Properties
Molecular Weight:192.00
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:190.9540837
Monoisotopic Mass:190.9540837
Topological Polar Surface Area:50.2
Heavy Atom Count:11
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4,6-Dichloro-2-pyridinecarboxylic acid
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