 Home > Encyclopedia > 3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile

3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile

3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile structure

CAS No:
473921-12-9
Formula:
C17H18N4O2
Chemical Name:
3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile
Synonyms:
Lersivirine(UK 453061);3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile;UK 453061

Description

Lersivirine(UK-453061) is a next-generation non-nucleoside reverse transcriptase inhibitor (NNRTI, IC50=119 nM) with a unique resistance profile that exhibits potent antiretroviral activity against wild-type human immunodeficiency virus and clinically relevant NNRTI-resistant strains.IC50 value: 0.119 uM [1]Target: NNRTIUK-453061(Compound 5) demonstrated excellent activity against large panels of wild type and drug-resistant HIV consistent with the encouraging profile demonstrated agains

Lersivirine is an aromatic ether.|Lersivirine has been used in trials studying the treatment of HIV-1.|Lersivirine is a next-generation, pyrazole non-nucleoside reverse transcriptase inhibitor. Lersivirine retains activity against HIV viruses with mutations at position Y181, which confers resistance to efavirenz, etravirine, and nevirapine.

3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile Basic Attributes

Molecular Weight：

310.35

Exact Mass：

310.142975

UNII：

R3ZGC15A9A

DSSTox ID：

DTXSID0057881

NCI Thesaurus Code：

C83872

Characteristics

PSA：

94.9

XLogP3：

2.1

Density：

1.2±0.1 g/cm3

Boiling Point：

455.382°C at 760 mmHg

Flash Point：

229.2±28.7 °C

Refractive Index：

1.595

Safety Information

Precautionary statement(s)：

P201, P202, P260, P273, P281, P308+P313, P314, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P260, P273, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 29 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

5-((3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile

Computed Properties

Molecular Weight:310.35
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:310.14297583
Monoisotopic Mass:310.14297583
Topological Polar Surface Area:94.9
Heavy Atom Count:23
Complexity:456
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Lersivirine(UK 453061)

CAS No.: 473921-12-9

Content: 99.00%

Inquiry
Creative Enzymes Contact Supplier

US
YRS

Business licensed Certified factory

Manufactory Supplier of Coenzymes,Inhibito,Enzymes,Zymogens,Substrates

Lersivirine

CAS No.: 473921-12-9

Content: 0.98%

Inquiry

Hot Searches: samarium oxide 3n price 2025; boric cid; clacium sulfate; linezolid 600 mg; butyl acetate for sale; retatrutide peptide buy usa price

Guide of 3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Recommended Suppliers

3-Cyano-5-[[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy]benzonitrile

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.