CVT-6883
-
CVT-6883
structure -
-
CAS No:
752222-83-6
-
Formula:
C21H21F3N6O2
-
Chemical Name:
CVT-6883
-
Synonyms:
3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoroMethyl)phenyl]Methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione;3-Ethyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,8H)-dione;CVT-6883;3-Ethyl-1-propyl-8-[1-(3-trifluoromethyl-benzyl)-1H-pyrazol-4-yl]-3,7-dihydro-purine-2,6-dione;GS6201 CVT6883
-
CAS No:
Description
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM)[1]. GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse[2]. GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice[3].
CVT-6883 is a selective, potent and orally available A2B-adenosine receptor antagonist which CV Therapeutics is investigating for the potential treatment of asthma and other conditions related to inflammation and fibrosis.
Drug Information
Investigated for use/treatment in asthma.
3-ethyl-1-propyl-8-(1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl)-3,7-dihydropurine-2,6-dione
Computed Properties
Molecular Weight:446.4
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:446.16780842
Monoisotopic Mass:446.16780842
Topological Polar Surface Area:87.1
Heavy Atom Count:32
Complexity:708
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes