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Emodepside

Emodepside structure

CAS No:
155030-63-0
Formula:
C60H90N6O14
Chemical Name:
Emodepside
Synonyms:
Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl;Emodepside;Cyclo(.alpha.R)-.alpha.-hydroxy-4-(4-morpholinyl)benzeneprop
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Emodepside is a cyclooctadepsipeptide consisting of D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, N-methyl-L-leucyl, D-lactoyl, N-methyl-L-leucyl, 3-[4-(4-morpholinyl)phenyl]-D-lactoyl, and N-methyl-L-leucyl residues joined in sequence to give a 24-membered macrocycle. An anthelmintic, it is used with praziquantel for the treatment and control of hookworm, roundworm and tapeworm infections in cats. It has a role as an antinematodal drug. It is a semisynthetic derivative and a cyclooctadepsipeptide.|Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively new class of anthelmintic.

Emodepside Basic Attributes

Molecular Weight：

1119.4

Exact Mass：

1118.652

EC Number：

604-993-7

UNII：

YZ647Y5GC9

DSSTox ID：

DTXSID50165799

ATC Code：

QP52AX60|QP52AA51

Characteristics

PSA：

211

XLogP3：

Safety Information

Precautionary statement(s)：

P260, P264, P270, P273, P301+P312, P314, P330, P391, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H372 (96.15%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]|P260, P264, P270, P273, P314, P391, and P501|Aggregated GHS information provided by 26 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

For dogs, when mixed parasitic infections caused by roundworms and coccidia of the following species are suspected or demonstrated:Roundworms (nematodes)Toxocara canis (mature adult, immature adult, L4);Uncinaria stenocephala (mature adult);Ancylostoma caninum (mature adult).CoccidiaIsospora ohioensis complex;Isospora canis.Procox is effective against the replication of Isospora and also against the shedding of oocysts. Although treatment will reduce the spread of infection, it will not be effective against the clinical signs of infection in already infected animals.|CatsFor cats suffering from, or at risk from, mixed parasitic infections caused by roundworms and tapeworms of the following species:Roundworms (Nematodes)Toxocara cati (mature adult, immature adult, L4 and L3);Toxocara cati (L3 larvae) – treatment of queens during late pregnancy to prevent lactogenic transmission to the offspring;Toxascaris leonina (mature adult, immature adult and L4);Ancylostoma tubaeforme (mature adult, immature adult and L4).Tapeworms (Cestodes)Dipylidium caninum (mature adult and immature adult);Taenia taeniaeformis (adult);Echinococcus multilocularis (adult).LungwormsAelurostrongylus abstrusus (adult).DogsFor dogs suffering from, or at risk from, mixed parasitic infections caused by roundworms and tapeworms of the following species:Roundworms (nematodes):Toxocara canis (mature adult, immature adult, L4 and L3);Toxascaris leonina (mature adult, immature adult and L4);Ancylostoma caninum (mature adult and immature adult);Uncinaria stenocephala (mature adult and immature adult);Trichuris vulpis (mature adult, immature adult and L4);Tapeworms (Cestodes):Dipylidium caninum;Taenia spp.;Echinococcus multilocularis (mature adult and immature);Echinococcus granulosus (mature adult and immature).

MeSH：

Drugs used to treat or prevent parasitic infections. (See all compounds classified as Antiparasitic Agents.)

MeSH Entry Terms：

emodepside

Emodepside Use and Manufacturing

Use Classification：

Veterinary drugs -> Procox -> EMA Drug Category|Antiparasitic products, insecticides and repellents -> Veterinary pharmacotherapeutic group|Veterinary drugs -> Profender -> EMA Drug Category

Computed Properties

Molecular Weight:1119.4
XLogP3:9
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:14
Exact Mass:1118.65150157
Monoisotopic Mass:1118.65150157
Topological Polar Surface Area:211
Heavy Atom Count:80
Complexity:1900
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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