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2,4-Dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol structure

CAS No:
1777-82-8
Formula:
C7H6Cl2O
Chemical Name:
2,4-Dichlorobenzyl alcohol
Synonyms:
Benzenemethanol,2,4-dichloro-;Benzyl alcohol,2,4-dichloro-;2,4-Dichlorobenzenemethanol;2,4-Dichlorobenzyl alcohol;Dybenal;Myacide SP;Rapidosept;Myacide;(2,4-Dichlorophenyl)methanol;NSC 15635
Categories:
Cosmetic Ingredient > Cosmetic Preservative

Description

white to light yellow crystal powdeChEBI: A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.

2,4-dichlorobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines. It has a role as an antiseptic drug. It is a member of benzyl alcohols and a dichlorobenzene.|Dichlorobenzyl alcohol is a mild antiseptic with a broad spectrum for bacterial and virus associated with mouth and throat infections. Dichlorobenzyl alcohol is considered as an active ingredient found in several marketed OTC products by Health Canada which has categorized this agent as an anatomical therapeutic chemical. On the other hand, dichlorobenzyl alcohol is categorized by the FDA in the inactive ingredient for approved drug products.

2,4-Dichlorobenzyl alcohol Basic Attributes

Molecular Weight：

177.03

Exact Mass：

177.03

BRN：

1448652

EC Number：

217-210-5

UNII：

1NKX3648J9

NSC Number：

15635

DSSTox ID：

DTXSID9041362

ATC Code：

R - Respiratory system

HScode：

29062900

Characteristics

PSA：

20.2

XLogP3：

2.5

Appearance：

White - light yellow crystals

Density：

1.2970 (rough estimate)

Melting Point：

59.5 °C

Boiling Point：

150 °C @ Press: 25 Torr

Flash Point：

>230 °F

Refractive Index：

1.5756 (estimate)

Water Solubility：

soluble in water, methanol and chloroform.

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

24/25

RTECS Number：

DO0890000

Marks：

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P271, P273, P280, P304+P312, P304+P340, P305+P351+P338, P310, P312, P501

Hazard Statements：

H318

GHS Classification：

|Danger|H318 (26.93%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|P261, P271, P273, P280, P304+P312, P304+P340, P305+P351+P338, P310, P312, and P501|Aggregated GHS information provided by 376 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity Summary：

Fertility and mutagenicity studies do not indicate any effect driven by dichlorobenzyl alcohol. Overdose studies indicate that in systemic overdose there might be a presence of a CNS transitory stimulation followed by CNS and cardiovascular. Chronic administration is not recommended as it might alter the normal microbial balance of the throat. depression In rats, the reported LD50 is of about 2.7 g/kg when administered orally.

Protein Binding：

This pharmacokinetic property has not been fully studied.

Drug Information

Drug Indication：

Dichlorobenzyl alcohol in combination with [DB13908] is available in over-the-counter products used for symptomatic relief of acute sore throat and postoperative sore throat.

Pharmacology：

In vitro studies with the combination of dichlorobenzyl alcohol and amylmetacresol have shown a virucidal against a number of viruses associated with the common cold which is observed by a reduction in the viral load. In clinical trials, administration of dichlorobenzyl alcohol lozenges has been shown to generate a reduced throat soreness and to provide pain relief and relief from difficulty in swallowing 5 minutes after administration. This effect can last for even 2 hours. The relief effect was shown to reach a steady-state after 45 minutes.

Absorption：

Dichlorobenzyl alcohol is released almost immediately from its formulation and reaches peak concentration after 3-4 minutes. The concentration in saliva after 120 minutes represents about 50% of the administered dose.|In preclinical trials, dermal administration of dichlorobenzyl alcohol results in renal elimination of 90% of the administered dose. After metabolism, dichlorobenzyl alcohol is excreted in the urine.|This pharmacokinetic property has not been fully studied.

Metabolism/Metabolites：

Dichlorobenzyl alcohol is metabolized in the liver to form hippuric acid.

Biological Half-Life：

This pharmacokinetic property has not been fully studied.

Mechanism of Action：

The use of dichlorobenzyl alcohol has been related to its antibacterial, antiviral and local anesthetic properties. The local anesthetic action of dichlorobenzyl alcohol is thought to be due to a reduced sodium channel blockade. The antiseptic mechanism of action of dichlorobenzyl alcohol is not fully understood but it is thought to be related to a denaturation of external proteins and rearrangement of the tertiary structure proteins.

MeSH Entry Terms：

dichlorobenzyl alcohol

2,4-Dichlorobenzyl alcohol Use and Manufacturing

Uses

An surgical antiseptic.

Use Classification：

Cosmetics -> Preservative

Computed Properties

Molecular Weight:177.02
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:175.9795702
Monoisotopic Mass:175.9795702
Topological Polar Surface Area:20.2
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 2,4-Dichlorobenzyl alcohol

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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2,4-Dichlorobenzyl alcohol

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