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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate

4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate structure

CAS No:
15427-93-7
Formula:
C20H28N10O4S
Chemical Name:
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
Synonyms:
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;NSC 109555 ditosylate;NSC 109555;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2);NSC109555 Dimesylate

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4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Basic Attributes

Molecular Weight：

504.56592

Exact Mass：

600.189686

Characteristics

PSA：

320

Appearance：

white to beige

Water Solubility：

H2O: soluble5mg/mL, clear (warmed)

Storage Conditions：

Store at -20°C

Safety Information

wgk germany：

4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Use and Manufacturing

NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.

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Guide of 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing

4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate

SDS

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