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1,2:5,6-Dianhydro-D-mannitol

1,2:5,6-Dianhydro-D-mannitol structure

CAS No:
19895-66-0
Formula:
C6H10O4
Chemical Name:
1,2:5,6-Dianhydro-D-mannitol
Synonyms:
D-Mannitol,1,2:5,6-dianhydro-;Mannitol,1,2:5,6-dianhydro-,D-;1,2:5,6-Dianhydro-D-mannitol;1,2:5,6-Dianhydromannitol;Dianhydromannitol;NSC 133129
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.

1,2:5,6-Dianhydro-D-mannitol Basic Attributes

Molecular Weight：

146.141

Exact Mass：

146.14

NSC Number：

133129|132313

Characteristics

PSA：

65.5

XLogP3：

-1.3

Density：

1.0945 (rough estimate)

Melting Point：

65-66 °C

Boiling Point：

185.74°C (rough estimate)

Refractive Index：

1.4310 (estimate)

Drug Information

MeSH：

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) (See all compounds classified as Antineoplastic Agents, Alkylating.)

MeSH Entry Terms：

dianhydromannitol|1,2,5,6-Dianhydrogalactitol

Computed Properties

Molecular Weight:146.14
XLogP3:-1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:146.05790880
Monoisotopic Mass:146.05790880
Topological Polar Surface Area:65.5
Heavy Atom Count:10
Complexity:122
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1,2:5,6-Dianhydro-D-mannitol

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Wuhan PNQ supply D-Mannitol, 1, 12:5,6 dianhydro

CAS No.: 19895-66-0

Grade: Chemical Grade

Content: 99%

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Guide of 1,2:5,6-Dianhydro-D-mannitol

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Recommended Suppliers
Latest News
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