2,4-Dichloro-3-iodopyridine

4-dichloro-3-iodo-pyridine (D5)To a solution of 2, 4-dichloropyridine (5.2 g, 35.137 mmol) and DIPEA (3.911 g, 38.651 mmol) in dry THF (40 ml) cooled at -78 To a solution of 2, 4-dichloropyridine (5.2 g, 35.137 mmol) and diisopropylamine (3.911 g, 38.651 mmol) in dry THF (40 ml) cooled at -78 To a solution of 2, 4-dichloropyridine (5.2 g, 35.137 mmol) and diisopropylamine (3.911 g, 38.651 mmol) in dry THF (40 ml) cooled at -78 2, 4-Dichloro-3 -iodo-pyridine (1-5)To a solution of 2, 4-dichloropyridine (5.2 g, 35.14 mmol) and DIPEA (3.91 g, 38.65 mmol) in dry THF (40 mL) cooled at -78 °C under a nitrogen atmosphere, was added n-BuLi (24.16 mL, 38.65 mmol, 1.6 M in hexanes) dropwise. The resulting r.m. was stirred at -78 °C for 45 min and then a solution of iodine (9.81 g, 38.651 mmol) in dry THF (20 mL) was added dropwise. The mixture was stirred at -78 °C for 1 h, allowed to warm to r. , diluted with EtOAc and quenched with HIntermediate 1 (1-1)2, 4-Dichloro-3-iodo-pyridine (1-1)To a solution of 2, 4-dichloropyridine (5.2 g, 35.14 mmol) and diisopropylamine (3.91 g, 38.65 mmol) in dry THF (40 mL) cooled at -78 °C under a nitrogen atmosphere, was added n-butyllithium (24.16 mL, 38.65 mmol, 1.6 M in hexanes) dropwise. The resulting reaction mixture was stirred at -78 °C for 45 min. and then a solution of iodine (9.81 g, 38.651 mmol) in dry THF (20 mL) was added dropwise. The mixture was stirred at -78 °C for 1 h., allowed to warm to r.t., diluted with EtOAc and quenched with HIntermediate 7 (1-7)2, 4-Dichloro-3 -iodo-pyridine (1-7) To a solution of 2, 4-dichloropyridine (5.2 g, 35.14 mmol) and DIPEA (3.91 g, 38.65 mmol) in dry THF (40 mL) cooled at -78 °C under a nitrogen atmosphere, was added n-butyllithium (24.16 mL, 38.65 mmol, 1.6 M in hexanes) dropwise. The resulting reaction mixture was stirred at -78 °C for 45 min. and then a solution of iodine (9.81 g, 38.651 mmol) in dry THF (20 mL) was added dropwise. The mixture was stirred at -78 °C for 1 h., allowed to warm to r.t., diluted with EtOAc and quenched with HIntermediate 1 (1-1)2, 4-Dichloro-3-iodo-pyridine (1-1)To a solution of 2, 4-dichloropyridine (5.2 g, 35.14 mmol) and diisopropylamine (3.91 g, 38.65 mmol) in dry THF (40 mL) cooled at -78 °C under a nitrogen atmosphere, was added n-butyllithium (24.16 mL, 38.65 mmol, 1.6 M in hexanes) dropwise. The resulting reaction mixture was stirred at -78 °C for 45 min. and then a solution of iodine (9.81 g, 38.651 mmol) in dry THF (20 mL) was added dropwise. The mixture was stirred at -78 °C for 1 h., allowed to warm to r.t., diluted with EtOAc and quenched with H2, 4-Dichloro-3-iodo-pyridine (I-1) 2, 4-Dichloro-3-iodo-pyridine (I-5) To a solution of 2, 4-dichloropyridine (5.2 g, 35.137 mmol) and diisopropylamine (3.911 g, 38.651 mmol) in dry THF (40 ml) cooled at -78 °C under a nitrogen atmosphere, was added n-butyllithium (24.157 ml, 38.651 mmol, 1.6 M in hexanes) dropwise. The resulting reaction mixture was stirred at -78 °C for 45 min and then a solution of iodine (9.81 g, 38.651 mmol) in dry THF (20 ml) was added dropwise. The mixture was stirred at -78 °C for 1 h, allowed to warm to rt, diluted with EtOAc and quenched with NH

Molecular Weight:273.88
XLogP3:3.1
Hydrogen Bond Acceptor Count:1
Exact Mass:272.86090
Monoisotopic Mass:272.86090
Topological Polar Surface Area:12.9
Heavy Atom Count:9
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes