3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

Synthesis Example 1N-bromosuccinimide(NBS) (27.5 g, 155 mmol) was slowly added, was warmed up to room temperatureovernight (18 hours) and the mixture was stirred. Water was added thereto andthe product was extracted with ethyl acetate (× 3). The organic layer waswashed with water (× 1) and saturated brine (× 1), and dried over anhydroussodium sulfate. After filtration, the filtrate was concentrated under reducedpressure, and the residue was purified by silica gel flash columnchromatography (n- hexane / ethyl acetate = 3/1), 2-amino-3, 5-dibromo-6-chloropyrazine (4) (16.8 g , 58.5 mmol, 94.7percent) as ayellow solid2-Amino-6-chloropyrazine (0.6 g, 4.63 mmol) was dissolved in MeOH (50 mL), and N-bromosuccinimide (1.81 g, 10.19 mmol) was added to the solution with stirring. The mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated, ethyl acetate was added and washed with water. The organic layer was dried over MgSOTo a solution of 6-chloro-pyrazin-2-ylamine (5.0 g, 38.8 mmol) in chloroform (194 mL) was added N-bromosuccinimide (20.7 g, 116 mmol) under a nitrogen atmosphere and the reaction mixture was stirred at room temperature for 5 h. The resulting mixture was poured into an aqueous solution of K

Molecular Weight:287.34
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:286.82835
Monoisotopic Mass:284.83040
Topological Polar Surface Area:51.8
Heavy Atom Count:10
Complexity:125
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes