Denibulin
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Denibulin
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CAS No:
284019-34-7
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Formula:
C18H19N5O3S
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Chemical Name:
Denibulin
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Synonyms:
DENIBULIN;[5-[[4-[[(2S)-2-Amino-1-oxopropyl]amino]phenyl]thio]-1H-benzimidazol-2-yl]carbamic acid methyl ester;Unii-K7037m241u;(S)-methyl (5-((4-(2-aminopropanamido)phenyl)thio)-1H-benzo[d]imidazol-2-yl)carbamate hydrochloride;CarbaMic acid, [5-[[4-[[(2S)-2-aMino-1-oxopropyl]aMino]phenyl]thio]-1H-benziMidazol-2-yl]-, Methyl ester;MN029;Denibulin, >=98%;GAOHLWCIAJNSEE-JTQLQIEISA-N
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CAS No:
Description
Denibulin is a novel small molecule Vascular Disrupting Agent under development by MediciNova for treatment of solid tumor cancers.|Denibulin is a small molecular vascular disrupting agent (VDA), with potential antimitotic and antineoplastic activities. Denibulin selectively targets and reversibly binds to the colchicine-binding site on tubulin and inhibits microtubule assembly. This results in the disruption of the cytoskeleton of tumor endothelial cells, ultimately leading to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation.
Drug Information
Investigated for use/treatment in solid tumors.
Denibulin selectively disrupts newly-formed tumor blood vessels, shutting down tumor blood flow and causing central necrosis of solid tumors. Consistent with its proposed mechanism of action, denibulin has been shown to reduce tumor blood flow resulting in tumor cell necrosis in rats bearing a human lung tumor xenograft. The present Phase I study now extends these findings (reductions in tumor blood flow) to cancer patients.
denibulin
Computed Properties
Molecular Weight:385.4
XLogP3:2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:385.12086066
Monoisotopic Mass:385.12086066
Topological Polar Surface Area:147
Heavy Atom Count:27
Complexity:529
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes