1,3-Dichloro-2-methoxy-5-nitrobenzene
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1,3-Dichloro-2-methoxy-5-nitrobenzene
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CAS No:
17742-69-7
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Formula:
C7H5Cl2NO3
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Chemical Name:
1,3-Dichloro-2-methoxy-5-nitrobenzene
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Synonyms:
Benzene,1,3-dichloro-2-methoxy-5-nitro-;Anisole,2,6-dichloro-4-nitro-;1,3-Dichloro-2-methoxy-5-nitrobenzene;3,5-Dichloro-4-methoxynitrobenzene;2,6-Dichloro-4-nitroanisole;NSC 212118
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CAS No:
Characteristics
55
3.2
light brown
1.5223 (rough estimate)
97-98 °C
305.6±37.0 °C(Predicted)
160 °C
1.6140 (estimate)
0.00147mmHg at 25°C
Safety Information
III
IRRITANT
2811
51/53-25
61-45-36/37
N-T,T,N
Toxic
P264, P270, P273, P301+P310, P321, P330, P391, P405, P501
H301
|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P301+P310, P321, P330, P391, P405, and P501|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|Not Classified
1,3-Dichloro-2-methoxy-5-nitrobenzene Use and Manufacturing
To a stirred solution of 2, 6-dichloro-4- nitrophenol (22) (6.0 g, 28.84 mmoles) in anhydrous DMF (60 mL) was added anhydrousKCO (15.9 g, 115.36 mmoles) and methyl iodide (23) (8.18 g, 57.69 mmoles) at 0°. The reaction mixture was heated at 60° for 6 hr. The resulting mixture was cooled to rt and poured into ice-water. The resulting solid was collected and dried in vacuo to give the cmde product. This was purified by column chromatography, eluting with Pet. Ether:EtOAc (85:15) to give 2.5 g (39.0percent yield) of pure product as an off-white solid. ‘HNMR (400 MHz, CDC13) ö 8.22 (s, 2H), 4.01 (s, 3H).To a stirred solution of 2, 6-dichloro-4- nitrophenol (22) (6.0 g, 28.84 mmoles) in anhydrous DMF (60 mL) was added anhydrousKCO (15.9 g, 115.36 mmoles) and methyl iodide (23) (8.18 g, 57.69 mmoles) at 0°. The reaction mixture was heated at 60° for 6 hr. The resulting mixture was cooled to rt and poured into ice-water. The resulting solid was collected and dried in vacuo to give the cmde product. This was purified by column chromatography, eluting with Pet. Ether:EtOAc (85:15) to give 2.5 g (39.0percent yield) of pure product as an off-white solid. ‘HNMR (400 MHz, CDC13) ö 8.22 (s, 2H), 4.01 (s, 3H).To a stirred solution of 2, 6-dichloro-4- nitrophenol (22) (6.0 g, 28.84 mmoles) in anhydrous DMF (60 mL) was added anhydrousKCO (15.9 g, 115.36 mmoles) and methyl iodide (23) (8.18 g, 57.69 mmoles) at 0. The reaction mixture was heated at 60 for 6 hr. The resulting mixture was cooled to rt and poured into ice-water. The resulting solid was collected and dried in vacuo to give the cmde product. This was purified by column chromatography, eluting with Pet. Ether:EtOAc (85:15) to give 2.5 g (39.0% yield) of pure product as an off-white solid. 'HNMR (400 MHz, CDC13) oe 8.22 (s, 2H), 4.01 (s, 3H).
1,3-Dichloro-2-methoxy-5-nitrobenzene
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