1,4-Dimethyl-1H-pyrazole-3-carboxylic acid

Reference Example 21 General procedure: To a stirred mixture of 4-[(4-bromo-2-methylphenyl)carbamoyl]pyridine-2-carboxylic acid (614 mg, 1.83 mmol, 1 equiv.) in DMF (10 mL) were added methanamine hydrochloride (185.5 mg, 2.75 mmol, 1.50 equiv.), DIEA (473.5 mg, 3.66 mmol, 2 equiv.) and HATEG (1044.9 mg, 2.75 mmol, 1.5 equiv.). The resulting mixture was stirred overnight at room temperature and then washed with water and extracted with EA. The combined organic layer was concentrated under reduced pressure and the residue was purified by Prep-TLC (CH2Cl2/MeOH=20: 1) to afford the title compound as a white solid in 69.45% yield.To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3, 4-dihydroquinolin-2(1H)-one (0.100 g, 0.408 mmol) and General procedure: To a stirred solution of N-(4-bromo-2-methylphenyl)-2-cyanopyridine-4- carboxamide (1 g, 3.16 mmol, 1 equiv.) in EtOH (20 mL) was added NaOH (20 mL, 2 M). The resulting mixture was stirred for 2 h at 60 C and then concentrated under reduced pressure. The aqueous layer was extracted with EA and the residue was acidified to pH 6 with HCl (1M). The resulting mixture was filtered, the filter cake was washed with water and the resulting solid was dried under infrared light to give the title compound as a yellow solid in 57.92% yield.Reference Example 21 Production of

Molecular Weight:140.14
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:140.058577502
Monoisotopic Mass:140.058577502
Topological Polar Surface Area:55.1
Heavy Atom Count:10
Complexity:149
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes