6,7-Dimethoxy-N-(4-phenoxyphenyl)-

Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.

Src Inhibitor-1 is a member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of quinazolines, a secondary amino compound, an aromatic ether and a polyether.

Src Kinase inhibitor 1lung cancers with EGF receptor abnormalities and is a potential candidate for mol.-targeted therapy

Molecular Weight:373.4
XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:373.14264148
Monoisotopic Mass:373.14264148
Topological Polar Surface Area:65.5
Heavy Atom Count:28
Complexity:466
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes