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2,3-Dimethoxy-1,4-naphthoquinone

2,3-Dimethoxy-1,4-naphthoquinone structure

CAS No:
6956-96-3
Formula:
C12H10O4
Chemical Name:
2,3-Dimethoxy-1,4-naphthoquinone
Synonyms:
1,4-Naphthalenedione,2,3-dimethoxy-;1,4-Naphthoquinone,2,3-dimethoxy-;2,3-Dimethoxy-1,4-naphthalenedione;2,3-Dimethoxy-1,4-naphthoquinone;2,3-Dimethoxy-p-naphthoquinone;2,3-Dimethoxynaphthoquinone;NSC 69355;2,3-Dimethoxy-1,4-dihydronaphthalene-1,4-dione

Description

DMNQ is a redox cycling agent that generates both superoxide and hydrogen peroxide intracellularly in a concentration dependent manner. DMNQ increases ROS generation[1].

2,3-dimethoxynaphthalene-1,4-dione is a naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis. It derives from a 1,4-naphthoquinone.

2,3-Dimethoxy-1,4-naphthoquinone Basic Attributes

Molecular Weight：

218.21

Exact Mass：

218.21

NSC Number：

69355

DSSTox ID：

DTXSID8040935

HScode：

2914690090

Characteristics

PSA：

52.6

XLogP3：

1.9

Appearance：

solid

Density：

1.28g/cm3

Melting Point：

112-114 °C

Flash Point：

177.6ºC

Refractive Index：

1.571

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2,3-dimethoxy-1,4-naphthoquinone

Computed Properties

Molecular Weight:218.20
XLogP3:1.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:218.05790880
Monoisotopic Mass:218.05790880
Topological Polar Surface Area:52.6
Heavy Atom Count:16
Complexity:322
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 2,3-Dimethoxy-1,4-naphthoquinone

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties

2,3-Dimethoxy-1,4-naphthoquinone

SDS

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