DOW FR-250 (OCTABROMOBIPHENYL)

785.37628

777.362305

248-696-7

4E96M09888

TSCA listed

White

0

8.70

3.5838 (rough estimate)

225°C

554.44°C (rough estimate)

265.4±23.5 °C

1.7040 (estimate)

25ug/L(25 ºC)

7X10-11 mm Hg at 28 deg C

LDLo orl-rat: 2000 mg/kg TXAPA9 22,316,72

4.1×103mol/(m3Pa) at 25℃, HSDB (2015)

Decomposes at 435 °C

II

9

3152

P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

3152

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, and P501

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Irritating to skin, eyes, and mucous membranes.

Octabromobiphenyl was a minor constituent in the product Firemaster BP-6, which was accidentally substituted for a cattle nutrient in feed sent to a number of farms in Michigan in 1973(1). The disposal of contaminated feed, animal carcasses (poultry, dairy cattle, swine) and animal products such as meat, eggs, and dairy products was a source of octabromobiphenyl emitted to the environment(1).

Octabromobiphenyl was detected in New Jersey soil and sludge samples at 90 and 3,600 ppb, respectively(1).

LD50 Rat (male) oral 2 g/kg bw /from table/|LD50 Rabbit dermal >10 g/kg bw /from table/|LD50 Rat oral >17 g/kg bw

Octabromobiphenyl's former production and use as an additive in flame retardant materials(1), may have resulted in its release to the environment through various waste streams(SRC). Most octabromobiphenyl produced in the US was exported and US production was discontinued in 1979(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 349,000(SRC), determined from a structure estimation method(2), indicates that octabromobiphenyl will be immobile in soil(SRC). Volatilization of octabromobiphenyl from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.4X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 7.0X10-11 mm Hg(3), and water solubility, 0.030 mg/L(4). Octabromobiphenyl is not expected to volatilize from dry soil surfaces(SRC) based on its vapor pressure(3). Biodegradation data for octabromobiphenyl were not available(SRC, 2005). Biodegradation data on polybrominated biphenyls such as hexabromobiphenyl indicate these compounds are persistent in the environment, but may slowly be degraded under anaerobic conditions(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 349,000(SRC), determined from a structure estimation method(2), indicates that octabromobiphenyl is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.4X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 7.0X10-11 mm Hg(4), and water solubility, 0.030 mg/L(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from a log Kow of 5.53(5) and regression derived equation(7) suggests the potential for bioconcentration in aquatic organisms is low (SRC). Static bioconcentration studies conducted using fish exposed to 14C-labeled octabromobiphenyl for 48 hours indicate that this compound does not bioconcentrate(9). Octabromobiphenyl is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(8). Brominated biphenyls have been shown to undergo direct photolysis in solutions(8), suggesting that there is potential for direct photolysis in sunlit surface waters(SRC). Biodegradation data for octabromobiphenyl were not available(SRC, 2005). Biodegradation data on polybrominated biphenyls such as hexabromobiphenyl indicate these compounds are persistent in the environment, but may slowly be degraded under anaerobic conditions(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), octabromobiphenyl, which has a vapor pressure of 7.0X10-11 mm Hg at 28 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase octabromobiphenyl may be removed from the air by wet and dry deposition(SRC). Brominated biphenyls have been shown to undergo direct photolysis in solutions(3); however, it is unclear whether direct photolysis will occur for particulate phase octabromobiphenyl in the atmosphere.

Octabromobiphenyl is subject to direct photolysis in the environment with the subsequent formation of lower brominated biphenyls as degradation products(1). In the atmosphere, octabromobiphenyl will exist primarily in the particulate-phase, thus reaction with photochemically produced hydroxyl radicals is expected to be a slow abiotic degradation process(1). Octabromobiphenyl is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(1).

An estimated BCF of 3 was calculated for octabromobiphenyl(SRC), using a log Kow of 5.53(1) and a regression-derived equation(2) According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Static bioconcentration studies using rainbow trout indicated that lower brominated biphenyls such as tetrabromobiphenyl bioconcentrated in fish; however, the highly brominated octabromobiphenyl and decabromobiphenyl did not bioconcentrate(4).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for octabromobiphenyl can be estimated to be 349,000(SRC). According to a classification scheme(2), this estimated Koc value suggests that octabromobiphenyl is expected to be immobile in soil(SRC).

The Henry's Law constant for octabromobiphenyl is estimated as 2.4X10-9 atm-cu m/mole(SRC) derived from its vapor pressure, 7.0X10-11 mm Hg(1), and water solubility, 0.030 mg/L(2). This Henry's Law constant indicates that octabromobiphenyl is expected to be essentially non-volatile from water and moist soil surfaces(3). Octabromobiphenyl is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

Octabromobiphenyl is no longer produced or used in the United States(1,2); therefore, the potential for occupational exposure and exposure to the general public is low(SRC).

...Increased bromine concentrations were found in the liver and adipose tissue of rats exposed continuously to a commercial mixture of octabromobiphenyl for 15 weeks, suggesting that absorption had occurred. /Commercial mixture/|Rats being fed diets containing 1, 10, 100, or 1000 ppm octabromobiphenyl for 2 or 4 weeks showed dose-related accumulation of bromine in fat, liver, and muscle at levels > 10 ppm. Levels in the muscles were 3-4 times lower than that in the fat and liver. ... At 18 weeks after treatment with 10 ppm, bromine levels in the fat, liver, and muscle were ~11, 1.5, and 2.4 times higher, respectively, than levels of bromine in these tissues from controls. At 18 weeks after treatment with 1000 ppm, bromine levels in the fat, liver, and muscle were ~ 800, 9, 27 times higher than the control levels respectively.|In contrast with the high absorption rate for the hexabromobiphenyl congener, a commercial octabromobiphenyl mixture (45.2% octa, 47% nona, 5.7% deca, 1.8% hepta) appeared to be less well absorbed by rats after administration of a single dose of 1 mg/kg. Within the first 24 hours after dosing, 61.9% of the dose was found in the feces. This indicates that at least 38.1% of the dose was absorbed, but absorption may have been higher, since biliary excretion may have occurred. /Commercial mixture/|Increased bromide concentrations were observed in the liver and adipose tissue of rats exposed continuously to vapors of a commercial octabromobiphenyl mixture (33% octa, 60% nona, 6% deca, 1% hepta) (3.5 pg octabromobiphenyl/L air at equilibrium) for 15 weeks. Relative to controls, the concentration of bromide in liver and fat was increased by 39 and 100%, respectively; bromide concentration in skeletal muscle was not affected by treatment. /Commercial mixture/|For more Absorption, Distribution and Excretion (Complete) data for OCTABROMOBIPHENYL (6 total), please visit the HSDB record page.

Fish (Salmo salar) fed octabromobiphenyl-contaminated food contained unidentified penta-, hexa-, and heptabromobiphenyls in addition to the octabromo biphenyls. It was not known whether the partially debrominated biphenyls were generated by the fish, or by the associated microflora.

/HUMAN EXPOSURE STUDIES/ No adverse dermal effects were observed on the arms or legs of subjects after a 6-day application of polymer fibers containing commercial octabromobiphenyl mixture under an occlusive covering. /Commercial mixture/

2,2',3',4,4',5,5',6-octabromobiphenyl

Commercial octabromobiphenyl (Bromkal 80) contained at least four compounds. Assays of two commercial octabromobiphenyls showed the following compositions: 1.0-1.8% heptabromobiphenyl, 33.0-45.2% octabromobiphenyl, 47.4-60.0% nonabromobiphenyl, and 5.7-6.0% decabromobiphenyl. Notably, the major component of commercial octabromobiphenyl was nonabromobiphenyl, and not octabromobiphenyl.

1,1'-Biphenyl, ar,ar,ar,ar,ar',ar',ar',ar'-octabromo-: INACTIVE|S - indicates a substance that is identified in a final Significant New Use Rule.|Octabromobiphenyl was a minor ingredient in the flame retardant Firemaster BP-6 and Firemaster FF-1. Production of octabromobiphenyl was discontinued in 1979.