Epoxomicin
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Epoxomicin
structure -
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CAS No:
134381-21-8
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Formula:
C28H50N4O7
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Chemical Name:
Epoxomicin
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Synonyms:
L-Threoninamide,N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-;L-Threoninamide,N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-;N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-threoninamide;BU 4061T;Epoxomicin
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CAS No:
Description
ChEBI: A tripeptide consisting of an Ile-Ile-Thr-NH2 sequence N-substituted on the threonamide amidic nitrogen with a (2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl group and with acetyl and meth l groups on the nitrogen of the isoleucine residue distal to the threonamide; a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.
Characteristics
157
3.32
solid
1.1±0.1 g/cm3
107-109°
795.7±60.0 °C at 760 mmHg
435.0±32.9 °C
1.504
−20°C
3.18E-25mmHg at 25°C
D24.5 -66.1 ± 0.4° (c = 0.5 in MeOH)
