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EBE-A 22

EBE-A 22 structure

CAS No:
229476-53-3
Formula:
C17H16BrN3O2
Chemical Name:
EBE-A 22
Synonyms:
EBE-A 22;N-(3-Bromophenyl)-6,7-dimethoxy-N-methyl-4-quinazolinamine;N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine;4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-N-methyl-

Description

EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.IC50 value: Target: The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designated EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic pro

EBE-A 22 Basic Attributes

Molecular Weight：

374.23184

Exact Mass：

373.04300

DSSTox ID：

DTXSID60416148

Characteristics

PSA：

47.48000

XLogP3：

4.17740

Density：

1.446±0.06 g/cm3(Predicted)

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)|Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. (See all compounds classified as Intercalating Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline

Computed Properties

Molecular Weight:374.2
XLogP3:4.2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:373.04259
Monoisotopic Mass:373.04259
Topological Polar Surface Area:47.5
Heavy Atom Count:23
Complexity:387
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

ALUMINUM 1 4 8 11 15 18 22 25-OCTABUTOX&

129707-63-7
Direct Black 22

6473-13-8
C.I. Vat Brown 22

8005-30-9
C.I. Basic Red 22 Formula

12221-52-2
C.I. Basic Blue 22 Formula

12217-41-3
DR 22 Formula

123618-01-9
Pigment Red 22 Structure

6448-95-9
Quaternium 22 Structure

51812-80-7
What is BIBW 22

137694-16-7
What is Reactive Red 22

19526-81-9

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Guide of EBE-A 22

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

EBE-A 22

SDS

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