ENMD-119
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ENMD-119
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CAS No:
864668-87-1
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Formula:
C20H25NO2
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Chemical Name:
ENMD-119
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Synonyms:
ENMD-119;ENMD 1198;IRC 110160;ENMD-119 (ENMD 1198)
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CAS No:
Drug Information
Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
ENMD-1198, a new chemical entity (NCE) based on a modified chemical structure of 2-methoxyestradiol (2ME2), is designed to decrease metabolism while retaining 2ME2's multiple mechanisms of action, including inducing apoptosis, disrupting microtubules, and inhibiting HIF-1 alpha. In preclinical studies, ENMD-1198 has been shown to be an orally active, antimitotic agent that leads to arrest of cell division and apoptosis in tumor cells. It also exerts antiangiogenic activity that further contributes to its overall antitumor effects.
2-methoxyoestra-1,3,5(10),16-tetraene-3-carboxamide
Computed Properties
Molecular Weight:311.4
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:311.188529040
Monoisotopic Mass:311.188529040
Topological Polar Surface Area:52.3
Heavy Atom Count:23
Complexity:516
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
- Hot Searches
- n2o5 name
- butan-2-ol
- phenol red
- mno2
- cholinoid
- bromobenzene