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Esomeprazole potassium

Esomeprazole potassium structure

CAS No:
161796-84-5
Formula:
C17H19N3O3S.K
Chemical Name:
Esomeprazole potassium
Synonyms:
1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,potassium salt (1:1);1H-Benzimidazole,5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,potassium salt,(S)-;1H-Benzimidazole,5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,potassium salt;(S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt;Esomeprazole potassium;(S)-Omeprazole potassium;Esomeprazole potassium salt
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Esomeprazole potassium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole potassium salt is a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis.

The S-isomer of omeprazole.

Esomeprazole potassium Basic Attributes

Molecular Weight：

384.51

Exact Mass：

383.07100

DSSTox ID：

DTXSID20167240

Characteristics

PSA：

85.45000

XLogP3：

3.55120

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

MeSH Entry Terms：

Esomeprazole

Computed Properties

Molecular Weight:383.5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:383.07059410
Monoisotopic Mass:383.07059410
Topological Polar Surface Area:81.5
Heavy Atom Count:25
Complexity:459
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes