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Hirsuteine

Hirsuteine structure

CAS No:
35467-43-7
Formula:
C22H26N2O3
Chemical Name:
Hirsuteine
Synonyms:
Indolo[2,3-a]quinolizine-2-acetic acid,3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-,methyl ester,(αE,2S,3R,12bR)-;Corynan-16-carboxylic acid,16,17,18,19-tetradehydro-17-methoxy-,methyl ester,(3β,16E)-;Indolo[2,3-a]quinolizine-2-acetic acid,3-ethenyl-1,2,3,4,6,7,12,12b-octahydro-α-(methoxymethylene)-,methyl ester,[2S-[2α(E),3β,12bα]]-;Hirsuteine;Δ18-Hirsutine;18,19-Didehydrohirsutine;3-Epicorynantheine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Hirsuteine is an indole alkaloid extracted from Uncaria genus. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes[1].

Hirsuteine is an alkaloid.

Hirsuteine Basic Attributes

Molecular Weight：

366.5 g/mol

Exact Mass：

366.45

UNII：

43X9C2G2W5

Characteristics

PSA：

54.56000

XLogP3：

3.75

Density：

1.2±0.1 g/cm3

Boiling Point：

533.2±50.0 °C at 760 mmHg

Flash Point：

276.3±30.1 °C

Refractive Index：

1.623

Drug Information

MeSH Entry Terms：

hirsuteine

Computed Properties

Molecular Weight:366.5
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:366.19434270
Monoisotopic Mass:366.19434270
Topological Polar Surface Area:54.6
Heavy Atom Count:27
Complexity:604
Defined Atom Stereocenter Count:3
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes