 Home > Encyclopedia > erythromycin A methoxime

erythromycin A methoxime

erythromycin A methoxime structure

CAS No:
53066-26-5
Formula:
C38H70N2O13
Chemical Name:
erythromycin A methoxime
Synonyms:
erythromycin A methoxime;9-(Methoxyimino)-9-deoxoerythromycin;9-Deoxo-9-[[methyloxy]imino]erythromycin;ErythroMycin A 9-MethoxiMe, Wy 48314;Erythromycin A-E-oxime;Erythromycin A-E-oximeLEXITHROMYCIN.
Categories:
Organic Chemistry > Lactones

Request for Quotation

erythromycin A methoxime Basic Attributes

Molecular Weight：

762.972

Exact Mass：

762.48779 g/mol

Characteristics

PSA：

198 Å²

Density：

1.26±0.1 g/cm3(Predicted)

Drug Information

MeSH Entry Terms：

erythromycin A methoxime

erythromycin A methoxime Use and Manufacturing

Lexithromycin is an early semi-synthetic erythromycin, prepared by reaction of the 9-keto moiety to methyl oxime. The structural change improves the pH stability profile and hydrophobicity of lexithromycin for better in vivo absorption. This same rationale was used to greater effect with roxithromycin and, as a result, lexithromycin was quickly superseded and has not been not extensively studied. Like all erythromycins, lexithromycin shows broad spectrum antibacterial activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.

Computed Properties

Molecular Weight:763.0
XLogP3:3.3
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:8
Exact Mass:762.48779029
Monoisotopic Mass:762.48779029
Topological Polar Surface Area:198
Heavy Atom Count:53
Complexity:1230
Defined Atom Stereocenter Count:18
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes