ethyl quinoline-2-carboxylate

yellow powder

A mixture of quinaldine acid (5) (2.0 g, 11.55 mmol), dried K60.0 mg (0.3 mmol) of ethyl 4, 4-diethoxy-2-butenoate obtained in the step (2) and 28.0 mg (0.3 mmol) of aniline dissolved in 1 mL of acetic acid in a reactor equipped with magnetic stirring. , The mixture was stirred and reacted at 80 ° C for 6 h.The TCL stops the heating after detecting the reaction. The product and the starting material were separated by preparative thin layer chromatography (PTLC). The eluent was a mixture of petroleum ether and ethyl acetate in a volume ratio of 6:1.Finally, 40.0 mg (0.2 mmol) of the ethyl quinolin-2-carboxylate was obtained.

Molecular Weight:201.22
XLogP3:2.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:201.078978594
Monoisotopic Mass:201.078978594
Topological Polar Surface Area:39.2
Heavy Atom Count:15
Complexity:230
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes