Ethyl (1-hydroxycyclohexyl)acetate

Reference Example 61; (1-Hydroxycyclohexyl) ethyl acetate; To a solution of cyclohexanone (9.52 g, 97.0 mmol), a zinc powder (7.6 g, 116.4 mmol) and a small amount of iodine in THF (100 ml) was added dropwise ethyl bromoacetate (11.8 ml, 106.7 mmol) under a nitrogen atmosphere, and the mixture was heated under reflux for 5 hrs. 10percent Sulfuric acid (100 ml) was carefully added under ice-cooling, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous MgS04, and concentrated under reduced pressure to give the title compound (17.2 g, 94percent) as a colorless oil.

Molecular Weight:186.25
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:186.125594432
Monoisotopic Mass:186.125594432
Topological Polar Surface Area:46.5
Heavy Atom Count:13
Complexity:171
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes