Ethyl4-Cyclopropyl-1,3-thiazole-2-carboxylate

A solution of 2-bromo-1-cyclopropyl-ethanone (intermediate 12) (6.80 g, 42.0 mmol) and amino-thioxo-acetic acid ethyl ester (intermediate 6) (4.66 g, 35.0 mmol) in ethanol (50 mL) was heated to reflux for 1 hour. The reaction mixture was concentrated to dryness. The residue was purified by the flash column chromatography (silica, hexanes/ethyl acetate=4:1) to afford the title compound (6.7 g, 98percent).MS calcd for (CA solution of 2-bromo-1-cyclopropyl-ethanone (intermediate 12) (6.80 g, 42.0 mmol) and amino-thioxo-acetic acid ethyl ester (intermediate 6) (4.66 g, 35.0 mmol) in ethanol (50 mL) was heated to reflux for 1 hour. The reaction mixture was concentrated to dryness. The residue was purified by the flash column chromatography (silica, hexanes/ethyl acetate=4:1) to afford the title compound (6.7 g, 98percent).MS calcd for (C

Molecular Weight:197.26
XLogP3:2.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:197.05104977
Monoisotopic Mass:197.05104977
Topological Polar Surface Area:67.4
Heavy Atom Count:13
Complexity:206
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes