Ethyl4-methylamino-3-nitrobenzoate

Ethyl 4-fluoro-3-nitrobenzoate (10.0 g, 46.9 mmol) prepared in the Step 1-1-1 was dissolved in methanol (40 ml), and triethylamine (10 ml, 70.4=01) was added thereto. Under an ice cooling, a 40percent methylamine-methanol solution (5.50 g, 70.4 mmol) was added to the mixture. After the resulting mixture was stirred for one hour under an ice cooling, ice water was added thereto. The precipitate was separated by filtration and washed with water. The washed product was subjected to through circulation drying overnight to give the title compound (10.4 g, 99percent) as a yellow powder. [0232]

Molecular Weight:224.21
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:224.07970687
Monoisotopic Mass:224.07970687
Topological Polar Surface Area:84.2
Heavy Atom Count:16
Complexity:264
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes