Ethyl 5-methylisoxazole-4-carboxylate

Colorless liquid

Ethyl-5-methylisoxazole-4-carboxylate:Ethyl ethoxymethyleneacetoacetate, 110.00 g (0.59 mol) was taken in methanol (330 ml) and cooled to -5 Solution of hydroxylamine hydrochloride (4.1 g, 0.059 mol) and sodium acetate (4.84 g, 0.059 mol) in water (10 ml) was added dropwise to a solution of compound 3 (11 g, 0.059 mol) in methanol (25 ml) at 0 °C. The mixture was stirred during overnight at room temperature followed by extraction with EtOAc (3 x 50 ml), the combined EtOAc extract was washed by aqueous sodium bicarbonate solution to minimize the impurities and dried over Na2SO4. After that the solvent was removed to afford 7.16 g (78 percent) of Ethyl-5-methylisoxazole-4-carboxylate as yellow oil, which was used directly in the next step.

Molecular Weight:155.15
XLogP3:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:155.058243149
Monoisotopic Mass:155.058243149
Topological Polar Surface Area:52.3
Heavy Atom Count:11
Complexity:149
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes