Ethyl 2-[5-(4-methylpiperazinyl)benzimidazol-2-yl]acetate

Taking 43 mmol 5 - (4 - methyl piperazinyl -1 - yl) -2 - nitroaniline (compound b) is dissolved in 150 ml of absolute ethanol, after fully dissolving loading in the 1st raw material storage tank 1 in; take 20 ml 3.6 wt percent of HCl is dissolved in 150 ml of absolute ethanol, after fully dissolving loading in the 2nd raw material storage tank 2 in; taking 65 mmol β - ethoxy - β imino - propionic acid ethyl ester hydrochloride (compound c) is dissolved in 150 ml ethanol, after fully dissolving loading in the 3rd raw material storage tank 3 in, namely 5 - (4 - methyl piperazinyl -1 - yl) -2 - nitroaniline with β - ethoxy - β imine has short ethyl ester hydrochloride in a molar ratio of 1: 1.5, the 1st raw material storage tank 1 and the 2nd raw material storage tank 2 at the same time the pump enters micro channel of the feed liquid in the reaction device, by the 1st micro-structure mixer 4 enters into the coil internal diameter is 0.5 mm, the volume of 50 ml of the 1st micro-structured reactor (reactor 1) reaction, set up the micro-reactor parameter: 1st step of the continuous flow rate is 1.4 ml/min, the reaction temperature is 80 °C, the dwell time of the 8 min, the reaction mainly producing the intermediate 4 - (4 - methyl piperazine -1 - yl) m-phenylenediamine; then the 3rd raw material storage tank 3 in the feed liquid and reactor 1 at the same time obtained effluent pumped into the 2nd micro-structure mixer 5 enters into the coil internal diameter is 0.5 mm, the volume of 50 ml of the 2nd micro-structured reactor (reactor 2) mixed in the reaction, set up the micro-reactor parameter: 2nd step of the continuous flow rate is 3 ml/min, the reaction temperature is 80 °C, dwell time 20 min. Concentrating the reaction solution, obtaining oil object, for 15 ml water oily dissolving, for CHAfter all the 5-(4-methyl-piperazin-1-yl)-2-nitroaniline had disappeared from the reaction, the solution was purged with NAfter all the 5-(4-methyl-piperazin-1-yl)-2-nitroaniline had disappeared from the reaction, the solution was purged with N

Molecular Weight:302.37
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:302.17427596
Monoisotopic Mass:302.17427596
Topological Polar Surface Area:61.5
Heavy Atom Count:22
Complexity:384
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes