ETHYL 2-(3-NITROPYRIDIN-2-YL)ACETATE

Ethyl 2-(3-amino-pyridin-2-yl)-acetate Under an atmosphere of nitrogen, Pd/C (10%, 1.36 g) was charged to a round bottom flask. c Ethyl 2-(3-amino-pyridin-2-yl)-acetate Under an atmosphere of nitrogen, Pd/C (10%, 1.36 g) was added to a round bottom flask. c Ethyl 2-(3-Amino-pyridin-2-yl)-acetate Under an atmosphere of nitrogen, Pd/C (10%, 1.36 g) was added to a round bottom flask. c) ethyl 2-(3-amino-pyridin-2-yl)-acetate Under an atmosphere of nitrogen, Pd/C (10%, 1.36 g) was charged to a round bottome flask.. To a degassed solution of H) ethyl (3-aminopyridin-2-yl)acetate A mixture of To a solution of the product obtained in Step 2 (2.0 g, 9.52 mmol) in DMF (28 mL), cooled at 0 C under a N2 atmosphere, NaH (419 mg, 10.47 mmol, 60 wt% dispersion in mineral oil) was added. After stirring for 30 min. at 0 C, iodoethane (0.84 mL, 10.47 mmol) was added and the reaction mixture was stirred at r.t. for 4 h. Then, the reaction mixture was again cooled to 0 C and additional NaH (419 mg, 10.47 mmol) was added. After stirring for 30 min. at 0 C, additional iodoethane (0.84 mL, 10.47 mmol) was added and the mixture was stirred at r.t. overnight. Water was added and it was extracted with EtOAc. The combined organic phases were dried over MgS04 and concentrated to dryness to afford a crude compound that was purified by flash chromatography, silica gel, gradient CH/EtOAc 100:0 to 0:100 to give the title compound (1 .7 g, 66% yield).

Molecular Weight:210.19
XLogP3:0.9
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:210.06405680
Monoisotopic Mass:210.06405680
Topological Polar Surface Area:85
Heavy Atom Count:15
Complexity:239
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes