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Eicosapentaenoic acid ethyl ester

Eicosapentaenoic acid ethyl ester structure

CAS No:
84494-70-2
Formula:
C22H34O2
Chemical Name:
Eicosapentaenoic acid ethyl ester
Synonyms:
EICOSAPENTAENOIC ACID ETHYL ESTER;EPA EE;ETHYL 5,8,11,14,17-EICOSAPENTAENOATE;ICOSAPENTAENOIC ACID ETHYL ESTER;5,8,11,14,17-eicosapentaenoicacid,ethylester;5,8,11,14,17-eicosapentaenoicacidethylester;5,8,11,14,17-Icosapentaenoic acid ethyl ester;Ethyl 5,8,11,14,17-eicosapentaenoate (all-cis)
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Ethyl icosapentate is an ester of a polyunsaturated acid derived from fish oil. It is reported to decrease platelet aggregation, reduce blood viscosity and increase erythrocyte deformability.

Ethyl eicosapentaenoate contains several double bonds and ester groups, with high reactivity, and can participate in a variety of organic chemical reactions, such as addition reactions and esterification reactions.

Eicosapentaenoic acid ethyl ester Basic Attributes

Molecular Weight：

330.5

Exact Mass：

330.50

DSSTox ID：

DTXSID7057814

Color/Form：

Clear Colourless

Characteristics

PSA：

26.30000

XLogP3：

7.32

Density：

0.909±0.06 g/cm3(Predicted)

Boiling Point：

417.0±34.0 °C(Predicted)

Flash Point：

103.094°C

Refractive Index：

1.496

Critical Temperature & Pressure：

Refrigerator

Drug Information

MeSH：

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)|Substances that alter the metabolism of LIPIDS. (See all compounds classified as Lipid Regulating Agents.)

MeSH Entry Terms：

5,8,11,14,17-eicosapentaenoic acid, ethyl ester, (5Z,8Z,11Z,14Z,17Z)-

Eicosapentaenoic acid ethyl ester Use and Manufacturing

Eicosapentaenoic Acid Ethyl Ester is used in the treatment of ischemic brain damage and reduce injury. Also used in the therapeutic treatment of statin-treated patients with persistent high triglycerides.

Computed Properties

Molecular Weight:330.5
XLogP3:6.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:15
Exact Mass:330.255880323
Monoisotopic Mass:330.255880323
Topological Polar Surface Area:26.3
Heavy Atom Count:24
Complexity:425
Undefined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has a strong effect on regulating blood lipids, inhibits the synthesis of lipids and lipoproteins in the liver, can reduce plasma cholesterol, triglycerides, LDL, VLDL, increase HDL, and also has vasodilation and anti-thrombotic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ethyl polyenoate soft capsules
Ingredients	Ethyl polyacrylate capsules
Indication	Not yet clear.
Specifications	0.25g (based on the sum of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester)
Manufacturer	Jiangsu Xinfu Pharmaceutical Co., Ltd.

Ethyl polyenoate soft capsules
Ingredients	The main ingredients of this product: Eicosapentaenoic acid ethyl ester.
Indication	The main ingredients of polyoleate capsules are ethyl eicosapentaenoic acid and ethyl docosahexaenoic acid, both of which contain more unsaturated bonds and have a strong effect on regulating blood lipids. They also have vasodilating and anti-thrombotic effects. The mechanism of action is to promote the excretion of neutral or acidic cholesterol from feces, inhibit the synthesis of lipids and lipoproteins in the liver, and can reduce plasma cholesterol, triglycerides, LDL, VLDL, and increase HDL.
Specifications	0.25g (including the sum of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester).
Manufacturer	Shandong Dyne Marine Organism Pharmaceutical Co., Ltd.

Ethyl polyenoate soft capsules
Ingredients	The main ingredients of this product: Eicosapentaenoic acid ethyl ester.
Indication	The main ingredients of polyoleate capsules are ethyl eicosapentaenoic acid and ethyl docosahexaenoic acid, both of which contain more unsaturated bonds and have a strong effect on regulating blood lipids. They also have vasodilating and anti-thrombotic effects. The mechanism of action is to promote the excretion of neutral or acidic cholesterol from feces, inhibit the synthesis of lipids and lipoproteins in the liver, and can reduce plasma cholesterol, triglycerides, LDL, VLDL, and increase HDL.
Specifications	0.25g (including the sum of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester)
Manufacturer	Tianjin Jun'an Biopharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

KD PHARMA BEXBACH GMBH

United States
Active
Zhongnuo Kailin Pharmaceutical Development (Suzhou) Co., Ltd.

China
Active
Parexel China Co., Ltd.

China
Active

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China Most Professional Manufacturer Supply High Quality Eicosapentaenoic acid ethyl ester CAS 84494-70-2

CAS No.: 84494-70-2

Grade: Pharmaceutical Grade

Content: 99%

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Guide of Eicosapentaenoic acid ethyl ester

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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