Epiroprim
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Epiroprim
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CAS No:
73090-70-7
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Formula:
C19H23N5O2
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Chemical Name:
Epiroprim
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Synonyms:
2,4-Pyrimidinediamine,5-[[3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl]methyl]-;5-[[3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl]methyl]-2,4-pyrimidinediamine;Ro 11-8958;Epiroprim
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CAS No:
Description
Epiroprim is a trimethoprim analogue and selective inhibitor of microbial dihydrofolate reductase, with antibacterial activity. Epiroprim inhibits the bacterial enzyme dihydrofolate reductase, selectively blocking the conversion of dihydrofolic acid to tetrahydrofolic acid. By depleting folate molecules, epiroprim inhibits bacterial nucleic acid synthesis.
Computed Properties
Molecular Weight:353.4
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:353.18517499
Monoisotopic Mass:353.18517499
Topological Polar Surface Area:101
Heavy Atom Count:26
Complexity:405
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes