Epilovastatin
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Epilovastatin
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CAS No:
79952-44-6
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Formula:
C24H36O5
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Chemical Name:
Epilovastatin
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Synonyms:
Butanoic acid,2-methyl-,(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester,(2R)-;Butanoic acid,2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester,[1S-[1α(S*),3α,7β,8β(2S*,4S*),8aβ]]-;Epilovastatin
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CAS No:
Description
White Solid
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Characteristics
72.83000
4.07
White Solid
1.1±0.1 g/cm3
108-110°C
559.2±50.0 °C at 760 mmHg
185.3±23.6 °C
1.532
-20°C Freezer
Safety Information
24/25
|Danger|H302 (31.47%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P314, P330, P405, and P501|Aggregated GHS information provided by 144 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Compounds that inhibit HYDROXYMETHYLGLUTARYL COA REDUCTASES. They have been shown to directly lower CHOLESTEROL synthesis. (See all compounds classified as Hydroxymethylglutaryl-CoA Reductase Inhibitors.)|Substances used to lower plasma cholesterol levels. (See all compounds classified as Anticholesteremic Agents.)
1 alpha-Isomer Lovastatin
Computed Properties
Molecular Weight:404.5
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:404.25627424
Monoisotopic Mass:404.25627424
Topological Polar Surface Area:72.8
Heavy Atom Count:29
Complexity:666
Undefined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes