11(12)-EpETE

(5Z,8Z,14Z,17Z)-11,12-epoxyicosatetraenoic acid is an EpETE obtained by formal epoxidation of the 11,12-double bond of all-cis-5,8,11,14,17-icosapentaenoic acid. It derives from an all-cis-5,8,11,14,17-icosapentaenoic acid. It is a conjugate acid of a (5Z,8Z,14Z,17Z)-11,12-epoxyicosatetraenoate.

Eicosapentaenoic acid (EPA; ) is converted to epoxyeicosatetraenoic acids (EpETE) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by binding large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)11(12)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.[Cayman Chemical]

Molecular Weight:318.4
XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:13
Exact Mass:318.21949481
Monoisotopic Mass:318.21949481
Topological Polar Surface Area:49.8
Heavy Atom Count:23
Complexity:432
Undefined Atom Stereocenter Count:2
Defined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes