Ethanone, 1-(5-amino-2-fluorophenyl)- (9CI)

A mixture of 1 -(2-fluoro-5-nitrophenyl) ethanone (0.3 g, 1 .64 mmol), Fe powder (0.27 g, 4.92 mmol), NH4CI (0.17 g, 3.28 mmol), iPrOH (12.8 ml) and H20 (3.2 ml)was ref luxed for 3 hours. The insoluble precipitate was filtered off and the organic layer was extracted with CH2CI2, dried over anhydrous MgSO4 and concentrated in vacuo to yield the product as yellow oil. The yellow oil obtained was purified by silica gel column chromatography (ethyl acetate: n-hexane = 1: 2, Rf = 0.3) to afford the title compound (0.19 g, 76percent).

Molecular Weight:153.15
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:153.058992041
Monoisotopic Mass:153.058992041
Topological Polar Surface Area:43.1
Heavy Atom Count:11
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes