ethyl 5-hydroxy-2-Methylnicotinate
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ethyl 5-hydroxy-2-Methylnicotinate
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CAS No:
60390-47-8
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Formula:
C9H11NO3
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Chemical Name:
ethyl 5-hydroxy-2-Methylnicotinate
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Synonyms:
ethyl 5-hydroxy-2-Methylnicotinate;5-hydroxy-2-methyl-nicotinic acid ethyl ester
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CAS No:
ethyl 5-hydroxy-2-Methylnicotinate Use and Manufacturing
Preparation of Compound A24:To a solution of A23 (10.0 g, 44.8 mmol) in MeOH (300 mL) was added potassium carbonate (12.4 g, 89.8 mmol). After stirred at room temperature for 12 hour, the mixture was poured into ice water. 2N HCl was added to adjust the pH to 8-9 and the mixture was extracted with ethyl acetate (2.x.100 mL). The organic layer was dried over NaExample 5f A21 A22 A23 A24 A25 A26 A27 [0431] Preparation of compound A22: To a solution of A21 (50.0 g, 0.303 mol) in DCM (200 mL) was added m-CPBA (80.0 g, 0.465 mol) at 0°C. After stirred at 0°C for 1 hour at room temperature for overnight, the mixture was poured into ice water. 2N NaOH was added to adjust the pH to 8-9 and the resultant mixture was extracted with DCM (3 x 200 mL). The organic layer was dried over Na
Computed Properties
Molecular Weight:181.19
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:181.07389321
Monoisotopic Mass:181.07389321
Topological Polar Surface Area:59.4
Heavy Atom Count:13
Complexity:184
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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ethyl 5-hydroxy-2-Methylnicotinate
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