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2-Hydroxy-4-methylpyridine

2-Hydroxy-4-methylpyridine structure

CAS No:
13466-41-6
Formula:
C6H7NO
Chemical Name:
2-Hydroxy-4-methylpyridine
Synonyms:
2-HYDROXY-4-PICOLINE;4-METHYL-2(1H)-PYRIDINONE;4-METHYL-2(1H)-PYRIDONE;4-METHYL-PYRIDIN-2-OL;4-METHYL-2-PYRIDINOL;4-METHYL-2-PYRIDONE;2-HYDROXY-4-METHYLPYRIDINE 97%;2-Hydroxy-4-Piocoline
Categories:
Organic Chemistry > Nitrogen Compounds

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Description

off-white to light brown crystalline powder

2-Hydroxy-4-methylpyridine Basic Attributes

Molecular Weight：

109.13

Exact Mass：

109.052765

BRN：

107082

EC Number：

-0

HScode：

29333995

Characteristics

PSA：

29.1

XLogP3：

0.1

Appearance：

off-white to light brown crystalline powder

Density：

1.1143 (rough estimate)

Melting Point：

131-134 °C(lit.)

Boiling Point：

186-187 °C12 mm Hg(lit.)

Flash Point：

186-187°C/12mm

Refractive Index：

1.5444 (estimate)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-40

safety instructions：

26-37/39-36-22

Marks：

Xi,Xn

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

2-Hydroxy-4-methylpyridine Use and Manufacturing

Synthesis of intermediate V-a: 4-Methyl-pyridin-2-olIntermediate V-a was prepared using the method of Adger et al, in J. Chem. Soc. Perkin Trans. 1, 1988, p2791 -2796. A 1 L flask containing water (240 mL) was treated with cone. HDiisopropylazodicarboxylate (290mg, 1.43mmol) was added dropwise, at ambient temperature, to a stirred solution of 5(R)-hydroxymethyl-3-(3-fluoro-4-(3, 6-dihydro-(2H)-pyran-4-yl)phenyl)oxazolidin-2-one (International Patent Application Publication WO 97/09328, 300mg, 1.02mmol), 2-hydroxy-4-methylpyridine (167mg, 1.53mmol) and triphenylphosphine (402mg, 1.53mmol) in THF (8ml). The resulting solution was stirred at ambient temperature for 30 minutes before evaporating the solvent to give an oil. The oil was purified by flash chromatography (Merck 9385 silica, ethyl acetate / isohexane(3:2) eluant) to give the title product (181mg, 46%) as a crystalline solid. 1H-NMR (300MHz, CDCl3): d = 2.52 (m, 2H), 3.92 (t, 2H), 3.97 (dd, 1H), 4.12 (t, 1H), 4.32 (m, 2H), 4.59 (d, 2H), 5.02 (m, 1H), 6.06 (m, 1H), 6.59 (s, 1H), 6.75 (d, 1H), 7.26 (m, 2H), 7.41 (dd, 1H), 7.99 (d, 1H). MS: ESP+ (M+H)+= 385.

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2-Hydroxy-4-methylpyridine

CAS No.: 13466-41-6

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Guide of 2-Hydroxy-4-methylpyridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
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2-Hydroxy-4-methylpyridine

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