5-Bromo-2-iodopyridine
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5-Bromo-2-iodopyridine
structure -
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CAS No:
223463-13-6
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Formula:
C5H3BrIN
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Chemical Name:
5-Bromo-2-iodopyridine
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Synonyms:
Pyridine,5-bromo-2-iodo-;5-Bromo-2-iodopyridine;2-Iodo-5-bromopyridine
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CAS No:
Characteristics
12.9
2.2
White to beige Crystalline Powder
2.3±0.1 g/cm3
117 °C
258.8°C at 760 mmHg
110.3±21.8 °C
1.666
0.0218mmHg at 25°C
Safety Information
IRRITANT, LIGHT SENSITIVE
NONH for all modes of transport
3
36/37/38
26-36-37/39
Xi
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 48 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
5-Bromo-2-iodopyridine Use and Manufacturing
Aqueous HI (57 percent) was added to 2, 5-dibromopyridine (12.60 g, 53.2 mmol) and Nal (11.40 g, 76 mmol). The resulting mixture was heated at reflux for 24 h, cooled and thendiluted with water (100 mL). The resulting mixture was basified with NaHCO3 and treated with Na2S2O4 until colourless. The mixture was extracted with DCM (5 x 60 mL) and the dried (Na2SO4) solvent removed under reduced pressure. The residue was collected by filtration and washed with Et20 (60 mL) and air dried to give the 5-bromo-2-iodopyridine (8.28 g, 55 percent) as a light grey powder.
Computed Properties
Molecular Weight:283.89
XLogP3:2.2
Hydrogen Bond Acceptor Count:1
Exact Mass:282.84936
Monoisotopic Mass:282.84936
Topological Polar Surface Area:12.9
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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