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Acecainide hydrochloride

Acecainide hydrochloride structure

CAS No:
34118-92-8
Formula:
C15H23N3O2.ClH
Chemical Name:
Acecainide hydrochloride
Synonyms:
Benzamide,4-(acetylamino)-N-[2-(diethylamino)ethyl]-,hydrochloride (1:1);Acetanilide,4′-[[2-(diethylamino)ethyl]carbamoyl]-,monohydrochloride;Benzamide,4-(acetylamino)-N-[2-(diethylamino)ethyl]-,monohydrochloride;N-Acetylprocainamide hydrochloride;N-Acetylprocaine amide hydrochloride;Acecainide hydrochloride;ASL 601;33091-33-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

yellow-beige crystalline powder

A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.

Acecainide hydrochloride Basic Attributes

Molecular Weight：

313.82

Exact Mass：

313.15600

EC Number：

251-831-2

UNII：

B9K738KX14

NSC Number：

759312

DSSTox ID：

DTXSID1045748

HScode：

29242998

Characteristics

PSA：

61.44000

XLogP3：

2.98250

Appearance：

powder

Melting Point：

190-193 °C

Boiling Point：

500ºC at 760mmHg

Flash Point：

256.2ºC

Water Solubility：

H2O: 50 mg/mL

Storage Conditions：

−20°C

Collision Cross Section：

170.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

safety instructions：

24/25

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

Acecainide

Acecainide hydrochloride Use and Manufacturing

Cardiac depressant (anti-arrhythmic).

Computed Properties

Molecular Weight:313.82
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:313.1557047
Monoisotopic Mass:313.1557047
Topological Polar Surface Area:61.4
Heavy Atom Count:21
Complexity:308
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes