4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide
-
4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide
structure -
-
CAS No:
342417-01-0
-
Formula:
C18H22N4O
-
Chemical Name:
4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide
-
Synonyms:
3-Pyridinecarboxamide,4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-;4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide;6-(4-Methylpiperazin-1-yl)-4-o-tolylnicotinamide
- Categories:
-
CAS No:
4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide Basic Attributes
310.39
310.39
608-960-8
DTXSID30467400
2933599090
4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide Use and Manufacturing
Step 3 Step 3: (0177) 1.0 g (4.05 mMol) 6-Chloro-4-o-tolyl-nicotinamide in 9.0 ml 1-methyl-piperazine was heated to 100° C. for 2 hours. The excess N-methyl-piperazine was removed under high vacuum and the residue was filtered on silica gel (eluent: dichloromethane) to yield 1.2 g (95percent) 6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide as a light yellow crystalline foam. (0178) MS (ISP): 311 (M+HIntermediate A-3 (582 mg, 1.625 mg) was dissolved in 10 ml of methanesulfonic acid and warmed to 100 ° C for 5 h. The reaction solution was poured into ice water and extracted with methyl tert-butyl ether.After the organic phase was combined, it was washed twice with water, the aqueous layer was combined, and the pH was adjusted to 14 with NaOH, and then extracted with methyl tert-butyl ether. The second organic layer was combined, washed successively with water, saturated brine, anhydrousDry over sodium sulfate.Pressurized distillation, The intermediate A-4 was purified to give a yield of 88percent.Step 3 Step 3: (0177) 1.0 g (4.05 mMol) 6-Chloro-4-o-tolyl-nicotinamide in 9.0 ml 1-methyl-piperazine was heated to 100° C. for 2 hours. The excess N-methyl-piperazine was removed under high vacuum and the residue was filtered on silica gel (eluent: dichloromethane) to yield 1.2 g (95percent) 6-(4-methyl-piperazin-1-yl)-4-o-tolyl-nicotinamide as a light yellow crystalline foam. (0178) MS (ISP): 311 (M+H
Computed Properties
Molecular Weight:310.4
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:310.17936134
Monoisotopic Mass:310.17936134
Topological Polar Surface Area:62.5
Heavy Atom Count:23
Complexity:408
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food AdditivesInquiryCAS No.: 342417-01-0Content: 99.00% -
![China]()
CN
2 YRS
Business licensedTrader Supplier of Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524,Milbemycin oxime,MeloxicamInquiryCAS No.: 342417-01-0Grade: Pharmaceutical GradeContent: 99% -
![China]()
CN
7 YRS
Business licensed Certified factoryManufactory Supplier of EncorafenibInquiryCAS No.: 342417-01-0Grade: Pharmaceutical GradeContent: 97% -
![China]()
CN
5 YRS
Business licensedTrader Supplier of PVC resin,pvc paste resin,melamineInquiryCAS No.: 342417-01-0Grade: Industrial GradeContent: 99% -
![China]()
CN
4 YRS
Business licensedTrader Supplier of Upadacitinib Hemihydrate,(S)-(+)-1-Boc-3-hydroxypyrrolidine
Learn More Other Chemicals
-
5-BROMOISOPHTHALALDEHYDE
120173-41-3
-
1-BROMO-3-IODO-5-TRIFLUOROMETHYL-BENZENE
481075-59-6
-
1-BROMO-1,1,2,2-TETRAFLUORO-4-IODOBUTANE
129587-49-1
-
4-BROMO-3-METHOXYANILINE Formula
19056-40-7
-
3-Bromo-6,8-dichloro-4H-1-benzopyran-4-one Formula
263365-49-7
-
1-BROMO-8-IODONAPHTHALENE Formula
4044-58-0
-
4-BROMO-3,5-DICHLOROFLUOROBENZENE Structure
263333-82-0
-
4-Bromo-2-methylisoindolin-1-one Structure
435273-55-5
-
What is 3-Bromopyrazine-2-carboxylic acid
937669-80-2
-
What is 3-Bromomethylbenzenesulfonyl chloride
148583-69-1
4-(2-Methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinecarboxamide
SDSRequest for Quotation