N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide
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![N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/75f5c2bd40354f939043a53d4d1bcd5b.png "N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide")
N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide
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CAS No:
1622902-68-4
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Formula:
C14H21N5O2S
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Chemical Name:
N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide
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Synonyms:
1-Propanesulfonamide,N-[cis-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-;N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide;N-[cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide;PF 04965842;Abrocitinib
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CAS No:
Description
Abrocitinib is under investigation in clinical trial NCT03796676 (JAK1 Inhibitor With Medicated Topical Therapy in Adolescents With Atopic Dermatitis).
N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide Basic Attributes
323.42
323.41
73SM5SF3OR
D - Dermatologicals
Safety Information
|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Treatment of atopic dermatitis
Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)
1-Propanesulfonamide, N-(cis-3-(methyl-7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)cyclobutyl)-
N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide Use and Manufacturing
Human Drugs -> EU pediatric investigation plans
Computed Properties
Molecular Weight:323.42
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:323.14159610
Monoisotopic Mass:323.14159610
Topological Polar Surface Area:99.4
Heavy Atom Count:22
Complexity:474
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Abrocitinib is a Janus kinase (JAK) 1 inhibitor that reversibly and selectively inhibits JAK1, regulates signaling pathways, and prevents the phosphorylation and activation of signal transducers and activators of transcription (STAT), thereby affecting cell hematopoietic function and immune cell function. Abrocitinib has higher selectivity for JAK1 than other JAK isozymes and can cause a dose-dependent decrease in serum inflammatory markers.
Registered Holders
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MAITHRI DRUGS PRIVATE LTD
Active
United States
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MICRO LABS LTD
Active
United States
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Nantong Chanyoo Pharmatech Co., Ltd.
Active
China
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N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide
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