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IDN 6556

IDN 6556 structure

CAS No:
254750-02-2
Formula:
C26H27F4N3O7
Chemical Name:
IDN 6556
Synonyms:
L-Alaninamide,N-[2-(1,1-dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-;N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide;IDN 6556;PF 03491390;Emricasan;624747-15-5
Categories:
Specialty Chemicals

Description

Emricasan (PF 03491390) is an irreversible pan-caspase inhibitor.

Emricasan is the first caspase inhibitor tested in human which has received orphan drug status by FDA. It is developed by Pfizer and made in such a way that it protects liver cells from excessive apoptosis.

IDN 6556 Basic Attributes

Molecular Weight：

569.5

Exact Mass：

569.50

UNII：

P0GMS9N47Q

DSSTox ID：

DTXSID10180160

Characteristics

PSA：

150.90000

XLogP3：

3.44610

Density：

1.4±0.1 g/cm3

Refractive Index：

1.550

Drug Information

Drug Indication：

Investigated for use/treatment in hepatitis (viral, C), liver disease, and transplantation (organ or tissue).|Treatment of non-alcoholic steatohepatitis (NASH)

Mechanism of Action：

IDN-6556 significantly improves markers of liver damage in patients infected with the Hepatitis C virus (HCV), an infection that affects up to 170m patients worldwide. IDN-6556 represents a new class of drugs that protect the liver from inflammation and cellular damage induced by viral infections and other causes. Various studies have also shown that it significantly lowers aminotransferase activity in HCV patients and appeared to be well tolerated.

MeSH Entry Terms：

3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

IDN 6556 Use and Manufacturing

Use Classification：

Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:569.5
XLogP3:3.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:11
Exact Mass:569.17851286
Monoisotopic Mass:569.17851286
Topological Polar Surface Area:151
Heavy Atom Count:40
Complexity:934
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Content: 99.00%

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Emricasan 99% see COA Kanbei kanbei

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